Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adenosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 4/20 | 0.89 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.89 |
| ▸ | ADORA2B known ✓ | P29275 | 1/20 | 0.89 |
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 0.89 |
| ▸ | DPP4 | P27487 | 1/20 | 0.89 |
| ▸ | MEN1 | O00255 | 1/20 | 0.89 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.89 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.89 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.89 |
| ▸ | GAPDH | P04406 | 1/20 | 0.89 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.89 |
| ▸ | STAT6 | P42226 | 1/20 | 0.89 |
| ▸ | PI4KA | P42356 | 1/20 | 0.89 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.89 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.89 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.89 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.89 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.89 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.89 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenosine SCHEMBL13362239 | 0.94 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| Adenosine SCHEMBL4522263 | 0.94 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| Adenosine SCHEMBL19107495 | 0.94 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| Adenosine SCHEMBL23804425 | 0.94 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| Adenosine SCHEMBL1821276 | 0.94 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| Adenosine SCHEMBL23420216 | 0.94 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| Adenosine SCHEMBL406207 | 0.94 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| Adenosine SCHEMBL24538665 | 0.94 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| Adenosine SCHEMBL2228590 | 0.94 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 | |
| Adenosine SCHEMBL2403819 | 0.94 | ADORA3 (1.00) | ADORA3DPP4MEN1SLC28A1MAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117535350-A | Gene therapy for age-related diseases and disorders | 哈佛学院董事及会员团体 | 2024-02-09 | — | — | CN | disclosed |
| CN-109844124-B | Gene therapy for age-related diseases and disorders | 哈佛学院董事及会员团体 | 2023-10-03 | — | — | CN | disclosed |
| US-20230220443-A1 | CHARACTERIZATION OF S-ADENOSYL-L-METHIONINE-CONSUMING ENZYMES WITH 1-STEP EZ-MTASE: A UNIVERSAL COUPLED-ASSAY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-07-13 | — | — | US | disclosed |
| WO-2023111095-A2 | ENGINEERED IMMUNE CELL | KING'S COLLEGE LONDON (GB) | 2023-06-22 | — | — | WO | disclosed |
| CN-116042482-A | Lactobacillus avium and application thereof in preparation of products for treating or relieving hyperuricemia | 中国农业大学 | 2023-05-02 | — | — | CN | disclosed |
| CN-110612353-A | RNA targeting of mutations via inhibitory tRNAs and deaminases | 加利福尼亚大学董事会 | 2019-12-24 | — | — | CN | disclosed |
| CN-109844124-A | Methods of gene therapy for age-related diseases and disorders | 哈佛学院董事及会员团体 | 2019-06-04 | — | — | CN | disclosed |
| WO-2018156464-A1 | CHARACTERIZATION OF S-ADENOSYL-L-METHIONINE-CONSUMING ENZYMES WITH 1-STEP EZ-MTASE: A UNIVERSAL COUPLED-ASSAY | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (US) | 2018-08-30 | — | — | WO | disclosed |
| EP-2306201-B1 | Methods and compositions for assaying homocysteine | GEN ATOMICS (US) | 2014-10-08 | — | — | EP | disclosed |
| EP-1644741-B1 | METHODS AND COMPOSITIONS FOR ASSAYING HOMOCYSTEINE | GEN ATOMICS (US) | 2011-08-31 | — | — | EP | disclosed |
| EP-2306201-A1 | Methods and compositions for assaying homocysteine | GENERAL ATOMICS (US) | 2011-04-06 | — | — | EP | disclosed |
| EP-2235201-A1 | METHODS AND COMPOSITIONS FOR ASSAYING HOMOCYSTEINE | GENERAL ATOMICS (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009089106-A1 | METHODS AND COMPOSITIONS FOR ASSAYING HOMOCYSTEINE | GENERAL ATOMICS (US) | 2009-07-16 | — | — | WO | disclosed |
| EP-1677665-A4 | DETERMINATION OF IONS USING ION-SENSITIVE ENZYMES | GEN ATOMICS (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1677665-A2 | DETERMINATION OF IONS USING ION-SENSITIVE ENZYMES | GENERAL ATOMICS (US) | 2006-07-12 | — | — | EP | disclosed |
| EP-1644741-A2 | METHODS AND COMPOSITIONS FOR ASSAYING HOMOCYSTEINE | GENERAL ATOMICS (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005027725-A2 | DETERMINATION OF IONS USING ION-SENSITIVE ENZYMES | GENERAL ATOMICS (US) | 2005-03-31 | — | — | WO | disclosed |
| WO-2005008252-A2 | METHODS AND COMPOSITIONS FOR ASSAYING HOMOCYSTEINE | GENERAL ATOMICS (US) | 2005-01-27 | — | — | WO | disclosed |
| WO-1999007877-A1 | BIOSENSOR FOR DETECTING ADENOSINE | THE UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS (GB) | 1999-02-18 | — | — | WO | disclosed |
| US-5583035-A | FOR BLOCKING MESSENGER RNA AND SUPPRESSING VIRUS REPRODUCTION | BAYER AKTIENGESELLSCHAFT (DE) | 1996-12-10 | — | — | US | disclosed |