Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | ITGAL | P20701 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9903830 | 0.87 | ALDH1A1 (0.42) | PBRM1ALDH1A1HPGDTSHRFEN1 | |
| SCHEMBL3954166 | 0.83 | ALDH1A1 (0.42) | PBRM1ALDH1A1HPGDTSHRFEN1 | |
| SCHEMBL15774546 | 0.82 | ALDH1A1 (0.41) | PBRM1ALDH1A1HPGDTSHRFEN1 | |
| SCHEMBL12497303 | 0.81 | CDC7 (0.34) | PBRM1KMT2A | |
| SCHEMBL320037 | 0.74 | ALDH1A1 (0.61) | PBRM1ALDH1A1HPGDTSHRFEN1 | |
| SCHEMBL14813627 | 0.73 | KDM4E (0.45) | ALDH1A1HPGDTSHRHSD17B10LMNA | |
| SCHEMBL29008206 | 0.72 | ALDH1A1 (0.58) | PBRM1ALDH1A1HPGDTSHRFEN1 | |
| SCHEMBL5740425 | 0.72 | ALDH1A1 (0.41) | PBRM1ALDH1A1HPGDTSHRFEN1 | |
| SCHEMBL27701506 | 0.70 | PNMT (0.55) | PBRM1ALDH1A1HPGDTSHRFEN1 | |
| SCHEMBL9902783 | 0.70 | CES2 (0.44) | PBRM1ITGB2ICAM1ITGALMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681215-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-04-22 | — | — | EP | claimed |