Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.46 |
| ▸ | CES1 | P23141 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | LOX | P28300 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.33 |
| ▸ | CCR2 | P41597 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30572325 | 0.80 | EGFR (0.44) | CES2CES1CA1CA2EGFR | |
| SCHEMBL2821403 | 0.78 | CES2 (0.44) | CES2CES1CA1DGAT1EGFR | |
| SCHEMBL3161665 | 0.77 | PLA2G7 (0.49) | CES2CES1CA1CA2TRPA1 | |
| SCHEMBL3176520 | 0.73 | KCNA3 (0.39) | PLA2G7 | |
| SCHEMBL15023129 | 0.73 | KIF11 (0.46) | DGAT1MAOAMAOBPLA2G7 | |
| SCHEMBL4328385 | 0.73 | CES2 (0.39) | CES2CES1CA1CA2CA4 | |
| SCHEMBL1661141 | 0.72 | ADRA2C (0.36) | — | |
| SCHEMBL11906148 | 0.71 | CES2 (0.38) | CES2CES1CA1CA2CA4 | |
| SCHEMBL3182714 | 0.70 | KIF11 (0.51) | CES2 | |
| SCHEMBL1799276 | 0.70 | CES2 (0.64) | CES2CES1CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681215-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-04-22 | — | — | EP | claimed |