Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPID | Q08752 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | RARG | P13631 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.51 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18171769 | 0.88 | PPID (0.64) | PPIDCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8050669 | 0.84 | ALDH1A1 (0.53) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL14064383 | 0.84 | PPID (0.64) | PPIDCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL19844612 | 0.81 | CYP2D6 (0.61) | PPIDCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9293928 | 0.80 | LMNA (0.59) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL6924120 | 0.80 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL23447175 | 0.80 | CYP1A2 (0.54) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9749394 | 0.80 | CYP1A2 (0.54) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL23905447 | 0.79 | CYP1A2 (0.60) | PPIDCYP1A2CYP3A4CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL27396621 | 0.79 | L3MBTL1 (0.54) | PPIDCYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057971-B1 | 1-(BETA-D-GLUCOPYRANOSYL)-1H-INDOLE COMPOUNDS | LILLY CO ELI (US) | 2018-12-12 | — | — | EP | disclosed |
| EP-3063162-B1 | GLUCOPYRANOSYL-SUBSTITUTED INDOLE-UREA DERIVATIVES AND THEIR USE AS SGLT INHIBITORS | LILLY CO ELI (US) | 2017-08-16 | — | — | EP | disclosed |
| EP-3063162-B1 | GLUCOPYRANOSYL-SUBSTITUTED INDOLE-UREA DERIVATIVES AND THEIR USE AS SGLT INHIBITORS | LILLY CO ELI (US) | 2017-08-16 | — | — | EP | disclosed |
| EP-3063162-A1 | GLUCOPYRANOSYL-SUBSTITUTED INDOLE-UREA DERIVATIVES AND THEIR USE AS SGLT INHIBITORS | Eli Lilly and Company (US) | 2016-09-07 | — | — | EP | disclosed |
| EP-3057971-A1 | 1 -(BETA-D-GLUCOPYRANOSYL)-1H-INDOLE COMPOUNDS | Eli Lilly and Company (US) | 2016-08-24 | — | — | EP | disclosed |
| US-9145435-B2 | Urea compounds | ELI LILLY AND COMPANY (US) | 2015-09-29 | — | — | US | disclosed |
| US-9145435-B2 | Urea compounds | ELI LILLY AND COMPANY (US) | 2015-09-29 | — | — | US | disclosed |
| US-9145435-B2 | Urea compounds | ELI LILLY AND COMPANY (US) | 2015-09-29 | — | — | US | disclosed |
| US-9145437-B2 | Urea compounds | ELI LILLY AND COMPANY (US) | 2015-09-29 | — | — | US | disclosed |
| US-9145437-B2 | Urea compounds | ELI LILLY AND COMPANY (US) | 2015-09-29 | — | — | US | disclosed |
| US-20150126469-A1 | NOVEL UREA COMPOUNDS | LILLY CO ELI (US) | 2015-05-07 | — | — | US | disclosed |
| US-20150126469-A1 | NOVEL UREA COMPOUNDS | LILLY CO ELI (US) | 2015-05-07 | — | — | US | disclosed |
| US-20150126469-A1 | NOVEL UREA COMPOUNDS | LILLY CO ELI (US) | 2015-05-07 | — | — | US | disclosed |
| WO-2015065956-A1 | GLUCOPYRANOSYL-SUBSTITUTED INDOLE-UREA DERIVATIVES AND THEIR USE AS SGLT INHIBITORS | ELI LILLY AND COMPANY (US) | 2015-05-07 | — | — | WO | disclosed |
| US-20150111846-A1 | NOVEL UREA COMPOUNDS | ELI LILLY AND COMPANY | 2015-04-23 | — | — | US | disclosed |
| US-20150111846-A1 | NOVEL UREA COMPOUNDS | ELI LILLY AND COMPANY | 2015-04-23 | — | — | US | disclosed |
| US-20150111846-A1 | NOVEL UREA COMPOUNDS | ELI LILLY AND COMPANY | 2015-04-23 | — | — | US | disclosed |
| WO-2015057953-A1 | 1 -(BETA-D-GLUCOPYRANOSYL)-1H-INDOLE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2015-04-23 | — | — | WO | disclosed |
| WO-2015057953-A1 | 1 -(BETA-D-GLUCOPYRANOSYL)-1H-INDOLE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2015-04-23 | — | — | WO | disclosed |
| CN-103539703-A | Synthesis method of 2-(3-isobutyl ureido) acetate | WUXI APPTEC TIANJIN CO LTD | 2014-01-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150111846-A1 | NOVEL UREA COMPOUNDS | SLC14A1, SLC10A1, UTS2R | PPID 3529/4885CYP1A2 1930/4885CYP3A4 1013/4885 |
| US-20150126469-A1 | NOVEL UREA COMPOUNDS | SLC14A1, SLC10A1, UTS2R | PPID 3529/4885CYP1A2 1930/4885CYP3A4 1013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.