Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16663491 | 0.82 | HDAC3 (0.59) | HDAC3HDAC1HDAC2HDAC6HDAC5 | |
| SCHEMBL16663488 | 0.81 | NPSR1 (0.43) | ALDH1A1HPGDKDM4EHTTMAPT | |
| SCHEMBL7011885 | 0.80 | MAPT (0.47) | ALDH1A1HPGDKDM4EHTTMAPT | |
| SCHEMBL20819193 | 0.69 | ALDH1A1 (0.65) | HDAC3HDAC1HDAC2HDAC6HDAC5 | |
| SCHEMBL9751601 | 0.68 | HSD17B10 (0.59) | HDAC3HDAC1HDAC2HDAC6HDAC5 | |
| SCHEMBL6421307 | 0.68 | ALDH1A1 (0.54) | HDAC3HDAC1HDAC2HDAC6HDAC5 | |
| SCHEMBL9550721 | 0.67 | HDAC3 (0.48) | HDAC3HDAC1HDAC2HDAC6HDAC5 | |
| SCHEMBL1722192 | 0.66 | MEN1 (0.54) | HDAC3HDAC1HDAC2HDAC6HDAC5 | |
| SCHEMBL7429124 | 0.66 | SMN1; SMN2 (0.53) | HDAC3HDAC1HDAC2HDAC6HDAC5 | |
| SCHEMBL10366553 | 0.66 | NCOA1 (0.52) | HDAC3HDAC1HDAC2HDAC6HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858999-B1 | AMIDES OF 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AND THEIR SALTS | GLENMARK PHARMACEUTICALS SA (CH) | 2017-05-10 | — | — | EP | disclosed |
| US-9458173-B2 | Amides of 2-amino-4-arylthiazole compounds and their salts | GLENMARK PHARMACEUTICALS S.A. (CH) | 2016-10-04 | — | — | US | disclosed |
| US-20150111038-A1 | AMIDES OF 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AND THEIR SALTS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150111038-A1 | AMIDES OF 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AND THEIR SALTS | AADAC, ABL2, ABL1 | HDAC3 801/4885HDAC1 711/4885HDAC2 177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.