Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16653274 | 0.80 | HDAC3 (0.49) | MAPTMAPK1ALDH1A1HSD17B10HPGD | |
| SCHEMBL16663488 | 0.79 | NPSR1 (0.43) | MAPTMAPK1ALDH1A1HSD17B10HPGD | |
| SCHEMBL8780843 | 0.73 | MAPT (0.49) | MAPTALDH1A1HSD17B10NPSR1SMN1; SMN2 | |
| SCHEMBL8314432 | 0.68 | HSD11B1 (0.56) | MAPTMAPK1ALDH1A1HSD17B10HPGD | |
| SCHEMBL25980052 | 0.67 | MAPT (0.62) | MAPTALDH1A1HSD17B10HPGDNPSR1 | |
| SCHEMBL28143902 | 0.66 | ALDH1A1 (0.39) | MAPTMAPK1ALDH1A1HSD17B10NPSR1 | |
| SCHEMBL20693128 | 0.64 | SMN1; SMN2 (0.41) | MAPTALDH1A1HSD17B10NPSR1GAA | |
| SCHEMBL8146166 | 0.63 | ALDH1A1 (0.58) | MAPTMAPK1ALDH1A1HSD17B10HPGD | |
| SCHEMBL15517362 | 0.63 | HSD17B10 (0.50) | MAPTMAPK1ALDH1A1HSD17B10HPGD | |
| SCHEMBL5278158 | 0.62 | ANPEP (0.64) | MAPTMAPK1ALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107973-B1 | NOVEL THIENO[2,3-d]PYRIMIDINEDIONES, PROCESS FOR THEIR PREPARATION AND USE THEREOF IN THERAPY | ASTRAZENECA AB (SE) | 2003-11-05 | — | — | EP | disclosed |
| US-6300334-B1 | DRUGS FOR TREATMENT OF RESPIRATORY SYSTEM DISORDERS | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |
| EP-1107973-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012514-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |