Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levomenthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 4/20 | 0.68 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.68 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menthol SCHEMBL2052642 | 1.00 | TRPM8 (0.68) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL1665362 | 0.93 | TRPM8 (0.72) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL27888021 | 0.92 | TRPM8 (0.62) | TRPM8TRPA1EPHX1SLC22A6 | |
| Menthol SCHEMBL28980170 | 0.91 | TRPA1 (0.60) | TRPM8TRPA1EPHX1SLC22A6 | |
| Menthol SCHEMBL13730660 | 0.90 | TRPM8 (0.68) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Levomenthol SCHEMBL29039984 | 0.90 | TRPA1 (0.58) | TRPM8TRPA1SLC22A6 | |
| Menthol SCHEMBL29157265 | 0.90 | TRPM8 (0.58) | TRPM8TRPA1EPHX1TRPV1CYP19A1 | |
| Palmitic Acid SCHEMBL28857858 | 0.90 | TRPA1 (0.58) | TRPM8TRPA1SLC22A6 | |
| Dodecanoate SCHEMBL18247782 | 0.90 | TRPA1 (0.58) | TRPM8TRPA1SLC22A6 | |
| Decanoic Acid SCHEMBL29053352 | 0.90 | TRPA1 (0.58) | TRPM8TRPA1SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960580-B2 | Process for making menthyl glutarate | RENESSENZ, LLC (US) | 2011-06-14 | — | — | US | disclosed |
| WO-2010123537-A2 | PROCESS FOR MAKING MENTHYL GLUTARATE | MILLENNIUM SPECIALTY CHEMICALS, INC. (US) | 2010-10-28 | — | — | WO | disclosed |
| US-20100274044-A1 | Process for making menthyl glutarate | RENESSENZ LLC | 2010-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100274044-A1 | Process for making menthyl glutarate | GCDH, ME3, ME2 | TRPM8 650/4885TRPA1 3543/4885EPHX1 1787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.