Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | S100A4 | P26447 | 2/20 | 0.41 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1666039 | 1.00 | TDP1 (0.50) | TDP1GPR35TSHRSMN1; SMN2GLA | |
| SCHEMBL8911863 | 0.84 | TDP1 (0.54) | TDP1GPR35TSHRSMN1; SMN2GLA | |
| SCHEMBL16225016 | 0.79 | TDP1 (0.58) | TDP1GPR35TSHRSMN1; SMN2GLA | |
| SCHEMBL10178321 | 0.79 | ALDH1A1 (0.54) | TDP1GPR35TSHRSMN1; SMN2GLA | |
| SCHEMBL888327 | 0.79 | ALDH1A1 (0.54) | TDP1GPR35TSHRSMN1; SMN2GLA | |
| SCHEMBL1666369 | 0.79 | ALDH1A1 (0.54) | TDP1GPR35TSHRSMN1; SMN2GLA | |
| SCHEMBL16268435 | 0.79 | TDP1 (0.48) | TDP1GPR35TSHRSMN1; SMN2GLA | |
| SCHEMBL4946630 | 0.78 | GPR35 (0.55) | TDP1GPR35TSHRSMN1; SMN2GLA | |
| SCHEMBL14028230 | 0.78 | GPR35 (0.55) | TDP1GPR35TSHRSMN1; SMN2GLA | |
| SCHEMBL18138439 | 0.78 | TDP1 (0.56) | TDP1GPR35TSHRSMN1; SMN2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10041115-B2 | 3′-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing | LASERGEN, INC. (US) | 2018-08-07 | — | — | US | disclosed |
| EP-2307565-B1 | REVERSIBLE NUCLEOSIDES AND NUCLEOTIDES TERMINATORS AND THEIR USE IN DNA SEQUENCING | LASERGEN INC (US) | 2017-11-29 | — | — | EP | disclosed |
| US-20170327886-A1 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | LASERGEN, INC. (US) | 2017-11-16 | — | — | US | disclosed |
| US-9689035-B2 | 3′-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing | LASERGEN, INC. (US) | 2017-06-27 | — | — | US | disclosed |
| CN-103588839-B | Nucleotides and nucleosides and method for their use in DNA sequencing | 激光基因公司 | 2017-04-12 | — | — | CN | disclosed |
| US-20160369336-A1 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | LASERGEN, INC. (US) | 2016-12-22 | — | — | US | disclosed |
| US-9399798-B2 | 3′-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing | LASERGEN, INC. (US) | 2016-07-26 | — | — | US | disclosed |
| US-9200319-B2 | Nucleotides and nucleosides and methods for their use in DNA sequencing | LASERGEN, INC. (US) | 2015-12-01 | — | — | US | disclosed |
| US-9200319-B2 | Nucleotides and nucleosides and methods for their use in DNA sequencing | LASERGEN, INC. (US) | 2015-12-01 | — | — | US | disclosed |
| US-20150176074-A1 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | LASERGEN, INC. (US) | 2015-06-25 | — | — | US | disclosed |
| US-20130122489-A1 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | AGILENT TECHNOLOGIES, INC. | 2013-05-16 | — | — | US | disclosed |
| WO-2013040257-A1 | 5-METHOXY. 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | LASERGEN, INC. (US) | 2013-03-21 | — | — | WO | disclosed |
| US-20130035237-A1 | Nucleotides and Nucleosides and Methods for their Use in DNA Sequencing | AGILENT TECHNOLOGIES, INC. | 2013-02-07 | — | — | US | disclosed |
| US-20130035237-A1 | Nucleotides and Nucleosides and Methods for their Use in DNA Sequencing | AGILENT TECHNOLOGIES, INC. | 2013-02-07 | — | — | US | disclosed |
| US-8148503-B2 | Nucleotides and nucleosides and methods for their use in DNA sequencing | LASERGEN, INC. (US) | 2012-04-03 | — | — | US | disclosed |
| US-8148503-B2 | Nucleotides and nucleosides and methods for their use in DNA sequencing | LASERGEN, INC. (US) | 2012-04-03 | — | — | US | disclosed |
| EP-2307565-A2 | NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN DNA SEQUENCING | Lasergen, Inc. (US) | 2011-04-13 | — | — | EP | disclosed |
| US-20100041041-A1 | NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN DNA SEQUENCING | AGILENT TECHNOLOGIES, INC. | 2010-02-18 | — | — | US | disclosed |
| US-20100041041-A1 | NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN DNA SEQUENCING | AGILENT TECHNOLOGIES, INC. | 2010-02-18 | — | — | US | disclosed |
| WO-2009152353-A2 | NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN DNA SEQUENCING | LASERGEN, INC. (US) | 2009-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041041-A1 | NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN DNA SEQUENCING | UNG, NT5C2, NT5E | TDP1 81/4885GPR35 3104/4885TSHR 4231/4885 |
| US-20150176074-A1 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | RNGTT, NT5C3B, NSUN2 | TDP1 154/4885GPR35 3197/4885TSHR 2303/4885 |
| US-10041115-B2 | 3′-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing | RNGTT, NT5C3B, NSUN2 | TDP1 157/4885GPR35 3199/4885TSHR 2333/4885 |
| US-20170327886-A1 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | RNGTT, NT5C3B, NSUN2 | TDP1 154/4885GPR35 3197/4885TSHR 2303/4885 |
| US-20160369336-A1 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | RNGTT, NT5C3B, NSUN2 | TDP1 154/4885GPR35 3197/4885TSHR 2303/4885 |
| US-20130035237-A1 | Nucleotides and Nucleosides and Methods for their Use in DNA Sequencing | UNG, NT5C2, NT5E | TDP1 81/4885GPR35 3104/4885TSHR 4231/4885 |
| US-20130122489-A1 | 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING | RNGTT, NT5C3B, NSUN2 | TDP1 154/4885GPR35 3197/4885TSHR 2303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.