Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16654377 | 1.00 | DRD2 (0.49) | DRD2HTR1AHTR2ADRD3ADRA2A | |
| SCHEMBL28006699 | 0.86 | DRD2 (0.49) | DRD2HTR1AHTR2ADRD3ADRA2A | |
| SCHEMBL18073602 | 0.86 | DRD2 (0.49) | DRD2HTR1AHTR2ADRD3ADRA2A | |
| SCHEMBL28006700 | 0.86 | DRD2 (0.49) | DRD2HTR1AHTR2ADRD3ADRA2A | |
| SCHEMBL18950691 | 0.85 | DRD2 (0.47) | DRD2HTR1AHTR2ADRD3ADRA2A | |
| SCHEMBL18950688 | 0.85 | DRD2 (0.47) | DRD2HTR1AHTR2ADRD3ADRA2A | |
| SCHEMBL21729939 | 0.84 | DRD2 (0.48) | DRD2HTR1AHTR2ADRD3ADRA2A | |
| SCHEMBL28006465 | 0.84 | DRD2 (0.48) | DRD2HTR1AHTR2ADRD3ADRA2A | |
| SCHEMBL29324645 | 0.84 | DRD2 (0.48) | DRD2HTR1AHTR2ADRD3ADRA2A | |
| SCHEMBL28006466 | 0.84 | DRD2 (0.48) | DRD2HTR1AHTR2ADRD3ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115806510-A | Synthetic method of 3- (trans) -4- (2-hydroxyethyl) cyclohexyl-1, 1-dimethylurea | 成都福柯斯医药技术有限公司 | 2023-03-17 | — | — | CN | claimed |
| CN-115806510-B | Synthesis method of 3-trans-4- (2-hydroxyethyl) cyclohexyl-1, 1-dimethylurea | 成都福柯斯医药技术有限公司 | 2023-04-21 | — | — | CN | disclosed |
| CN-115806510-B | Synthesis method of 3-trans-4- (2-hydroxyethyl) cyclohexyl-1, 1-dimethylurea | 成都福柯斯医药技术有限公司 | 2023-04-21 | — | — | CN | disclosed |
| CN-115806510-A | Synthetic method of 3- (trans) -4- (2-hydroxyethyl) cyclohexyl-1, 1-dimethylurea | 成都福柯斯医药技术有限公司 | 2023-03-17 | — | — | CN | disclosed |
| CN-115806510-A | Synthetic method of 3- (trans) -4- (2-hydroxyethyl) cyclohexyl-1, 1-dimethylurea | 成都福柯斯医药技术有限公司 | 2023-03-17 | — | — | CN | disclosed |
| CN-115806510-A | Synthetic method of 3- (trans) -4- (2-hydroxyethyl) cyclohexyl-1, 1-dimethylurea | 成都福柯斯医药技术有限公司 | 2023-03-17 | — | — | CN | disclosed |
| WO-2020034946-A1 | METHOD FOR PREPARING CYCLOHEXANE DERIVATIVE | 浙江京新药业股份有限公司 | 2020-02-20 | — | — | WO | disclosed |
| US-9718795-B2 | 1,4-cyclohexylamine derivatives and processes for the preparation thereof | CHEMO RESEARCH, S.L. (ES) | 2017-08-01 | — | — | US | disclosed |
| US-9718795-B2 | 1,4-cyclohexylamine derivatives and processes for the preparation thereof | CHEMO RESEARCH, S.L. (ES) | 2017-08-01 | — | — | US | disclosed |
| US-9718795-B2 | 1,4-cyclohexylamine derivatives and processes for the preparation thereof | CHEMO RESEARCH, S.L. (ES) | 2017-08-01 | — | — | US | disclosed |
| EP-3057942-B1 | 1,4-CYCLOHEXYLAMINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | CHEMO RES S L (ES) | 2017-06-14 | — | — | EP | disclosed |
| EP-3057942-B1 | 1,4-CYCLOHEXYLAMINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | CHEMO RES S L (ES) | 2017-06-14 | — | — | EP | disclosed |
| US-20160257661-A1 | 1,4-CYCLOHEXYLAMINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | CHEMO RESEARCH, S.L. (ES) | 2016-09-08 | — | — | US | disclosed |
| US-20160257661-A1 | 1,4-CYCLOHEXYLAMINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | CHEMO RESEARCH, S.L. (ES) | 2016-09-08 | — | — | US | disclosed |
| US-20160257661-A1 | 1,4-CYCLOHEXYLAMINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | CHEMO RESEARCH, S.L. (ES) | 2016-09-08 | — | — | US | disclosed |
| EP-3057942-A1 | 1,4-CYCLOHEXYLAMINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | Chemo Research, S.L. (ES) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015056164-A1 | 1,4-CYCLOHEXYLAMINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | CHEMO RESEARCH, S.L. (ES) | 2015-04-23 | — | — | WO | disclosed |
| WO-2015056164-A1 | 1,4-CYCLOHEXYLAMINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | CHEMO RESEARCH, S.L. (ES) | 2015-04-23 | — | — | WO | disclosed |
| CN-104496854-A | 3-cyclohexyl-1,1-dimethylurea compound as well as preparation method and application thereof | SHANGHAI INST PHARM INDUSTRY | 2015-04-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160257661-A1 | 1,4-CYCLOHEXYLAMINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | CYP4Z1, PNMT, HTR5A | DRD2 20/4885HTR1A 10/4885HTR2A 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.