Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.38 |
| ▸ | LOX | P28300 | 1/20 | 0.38 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | TPO | P07202 | 1/20 | 0.35 |
| ▸ | EPX | P11678 | 1/20 | 0.35 |
| ▸ | LPO | P22079 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1897083 | 0.86 | NOS3 (0.50) | NR4A1CYP3A4TSHRALDH1A1MAPK1 | |
| SCHEMBL29834775 | 0.83 | NR4A1 (0.41) | NR4A1ALDH1A1SCN9ALOXLOXL3 | |
| SCHEMBL573471 | 0.83 | NR4A1 (0.41) | NR4A1ALDH1A1SCN9ALOXLOXL3 | |
| SCHEMBL273483 | 0.83 | NR4A1 (0.61) | NR4A1CYP3A4TSHRALDH1A1MAPK1 | |
| SCHEMBL573928 | 0.82 | MAOA (0.53) | CYP3A4TSHRALDH1A1MAPK1SCN9A | |
| SCHEMBL20040909 | 0.80 | CYP3A4 (0.43) | NR4A1CYP3A4ALDH1A1SCN9ALOX | |
| SCHEMBL27849454 | 0.80 | NR4A1 (0.41) | NR4A1SCN9ALOXLOXL3LOXL2 | |
| SCHEMBL16029077 | 0.79 | LOX (0.40) | SCN9ALOXLOXL3LOXL2SCN5A | |
| SCHEMBL2473816 | 0.79 | KMO (0.50) | ALDH1A1KDM4E | |
| SCHEMBL1137124 | 0.79 | RAF1 (0.53) | SCN9AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |