Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 11/20 | 0.85 |
| ▸ | LMNA | P02545 | 5/20 | 0.85 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.85 |
| ▸ | PGR | P06401 | 4/20 | 0.85 |
| ▸ | AR | P10275 | 2/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.85 |
| ▸ | MEN1 | O00255 | 1/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.83 |
| ▸ | MAPT | P10636 | 1/20 | 0.83 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.83 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.83 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.83 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.61 |
| ▸ | ESR1 | P03372 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13596225 | 1.00 | NR3C1 (0.85) | NR3C1LMNAHIF1APGRAR | |
| SCHEMBL13181632 | 1.00 | NR3C1 (0.85) | NR3C1LMNAHIF1APGRAR | |
| Fluocinonide SCHEMBL2800723 | 0.92 | HIF1A (1.00) | NR3C1LMNAHIF1APGRAR | |
| Fluocinonide SCHEMBL13072779 | 0.92 | HIF1A (1.00) | NR3C1LMNAHIF1APGRAR | |
| SCHEMBL1979927 | 0.92 | NR3C1 (0.88) | NR3C1LMNAHIF1APGRAR | |
| Fluocinonide SCHEMBL9338347 | 0.92 | HIF1A (1.00) | NR3C1LMNAHIF1APGRAR | |
| Fluocinonide SCHEMBL4262 | 0.92 | HIF1A (1.00) | NR3C1LMNAHIF1APGRAR | |
| Fluocinonide SCHEMBL13568069 | 0.92 | HIF1A (1.00) | NR3C1LMNAHIF1APGRAR | |
| SCHEMBL21795341 | 0.92 | NR3C1 (0.83) | NR3C1LMNAHIF1APGRAR | |
| Fluocinonide SCHEMBL2962841 | 0.92 | HIF1A (1.00) | NR3C1LMNAHIF1APGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9012435-B2 | Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology | NICOX S.A. (FR) | 2015-04-21 | — | — | US | disclosed |
| US-9012435-B2 | Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology | NICOX S.A. (FR) | 2015-04-21 | — | — | US | disclosed |