Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 11/20 | 0.83 |
| ▸ | LMNA | P02545 | 5/20 | 0.83 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.83 |
| ▸ | PGR | P06401 | 4/20 | 0.83 |
| ▸ | AR | P10275 | 2/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.83 |
| ▸ | MEN1 | O00255 | 1/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.81 |
| ▸ | MAPT | P10636 | 1/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.81 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | ESR1 | P03372 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16656251 | 0.92 | NR3C1 (0.85) | NR3C1LMNAHIF1APGRAR | |
| SCHEMBL13181632 | 0.92 | NR3C1 (0.85) | NR3C1LMNAHIF1APGRAR | |
| SCHEMBL13596225 | 0.92 | NR3C1 (0.85) | NR3C1LMNAHIF1APGRAR | |
| SCHEMBL11871152 | 0.91 | NR3C1 (0.76) | NR3C1LMNAHIF1APGRAR | |
| Procinonide SCHEMBL8410 | 0.91 | NR3C1 (0.86) | NR3C1LMNAHIF1APGRAR | |
| Fluocinonide SCHEMBL4262 | 0.91 | HIF1A (1.00) | NR3C1LMNAHIF1APGRAR | |
| Fluocinonide SCHEMBL13568069 | 0.91 | HIF1A (1.00) | NR3C1LMNAHIF1APGRAR | |
| Fluocinonide SCHEMBL9338347 | 0.91 | HIF1A (1.00) | NR3C1LMNAHIF1APGRAR | |
| SCHEMBL1979927 | 0.91 | NR3C1 (0.88) | NR3C1LMNAHIF1APGRAR | |
| Fluocinonide SCHEMBL2800723 | 0.91 | HIF1A (1.00) | NR3C1LMNAHIF1APGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691950-B2 | Isoquinoline-steroid conjugates and uses thereof | AERIE PHARMACEUTICALS, INC. (US) | 2023-07-04 | — | — | US | disclosed |
| US-11059789-B2 | Isoquinoline-steroid conjugates and uses thereof | AERIE PHARMACEUTICALS, INC. (US) | 2021-07-13 | — | — | US | disclosed |
| US-20200071275-A1 | ISOQUINOLINE-STEROID CONJUGATES AND USES THEREOF | ALCON INC. (CH) | 2020-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200071275-A1 | ISOQUINOLINE-STEROID CONJUGATES AND USES THEREOF | GRK1, TNK2, CYP11B2 | NR3C1 173/4885LMNA 1670/4885HIF1A 3238/4885 |
| US-11059789-B2 | Isoquinoline-steroid conjugates and uses thereof | GRK1, TNK2, CYP11B2 | NR3C1 173/4885LMNA 1670/4885HIF1A 3238/4885 |
| US-11691950-B2 | Isoquinoline-steroid conjugates and uses thereof | GRK1, TNK2, CYP11B2 | NR3C1 173/4885LMNA 1670/4885HIF1A 3238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.