Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1663454 | 0.83 | SMN1; SMN2 (0.48) | ALDH1A1KDM4ERAB9ANPC1HPGD | |
| SCHEMBL1664302 | 0.83 | KCNK2 (0.44) | ALDH1A1KDM4ERAB9AAKR1C3AKR1C2 | |
| SCHEMBL1663491 | 0.83 | AKR1C3 (0.40) | ALDH1A1KDM4ERAB9AAKR1C3AKR1C2 | |
| SCHEMBL1743550 | 0.82 | ALDH1A1 (0.50) | ALDH1A1KDM4ERAB9ATRPM4AKR1C3 | |
| SCHEMBL1663199 | 0.79 | AKR1C3 (0.37) | ALDH1A1KDM4ERAB9AAKR1C3AKR1C2 | |
| SCHEMBL1663903 | 0.78 | CTSK (0.45) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1663905 | 0.78 | CTSK (0.45) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1663492 | 0.76 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL1743408 | 0.75 | ALDH1A1 (0.51) | ALDH1A1KDM4ERAB9ATRPM4GRIK1 | |
| SCHEMBL13178173 | 0.74 | ALDH1A1 (0.50) | ALDH1A1KDM4ERAB9ATRPM4GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305652-A2 | Trisubstituted quinazolinone derivatives as vanilloid antagonists | Novartis AG (CH) | 2011-04-06 | — | — | EP | disclosed |
| US-20090082365-A1 | Trisubstituted Quinazolinone Derivatives as Vanilloid Antagonists | NOVARTIS AG | 2009-03-26 | — | — | US | disclosed |
| US-20090082365-A1 | Trisubstituted Quinazolinone Derivatives as Vanilloid Antagonists | NOVARTIS AG | 2009-03-26 | — | — | US | disclosed |
| EP-1963283-A2 | TRISUBSTITUTED QUINAZOLINONE DERIVATIVES AS VANILLOID ANTAGONISTS | Novartis AG (CH) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007065662-A2 | TRISUBSTITUTED QUINAZOLINONE DERIVATIVES AS VANILLOID ANTAGONISTS | NOVARTIS AG (CH) | 2007-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082365-A1 | Trisubstituted Quinazolinone Derivatives as Vanilloid Antagonists | TRPV1, TRPV3, TRPV5 | ALDH1A1 2499/4885KDM4E 2742/4885RAB9A 566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.