Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetaminophen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.83 |
| ▸ | MAPT | P10636 | 3/20 | 0.83 |
| ▸ | MEN1 | O00255 | 3/20 | 0.83 |
| ▸ | CA1 | P00915 | 3/20 | 0.83 |
| ▸ | CA2 | P00918 | 3/20 | 0.83 |
| ▸ | CA12 | O43570 | 2/20 | 0.83 |
| ▸ | CA9 | Q16790 | 2/20 | 0.83 |
| ▸ | BRD4 | O60885 | 1/20 | 0.83 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.83 |
| ▸ | MB | P02144 | 1/20 | 0.83 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.83 |
| ▸ | CA3 | P07451 | 1/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.83 |
| ▸ | RARG | P13631 | 1/20 | 0.83 |
| ▸ | TSHR | P16473 | 1/20 | 0.83 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.83 |
| ▸ | CA4 | P22748 | 1/20 | 0.83 |
| ▸ | CA7 | P43166 | 1/20 | 0.83 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetaminophen SCHEMBL3480 | 0.91 | KMT2A (1.00) | KMT2AALDH1A1MAPTMEN1CA1 | |
| Acetaminophen SCHEMBL252939 | 0.91 | KMT2A (1.00) | KMT2AALDH1A1MAPTMEN1CA1 | |
| Acetaminophen SCHEMBL8937727 | 0.91 | KMT2A (1.00) | KMT2AALDH1A1MAPTMEN1CA1 | |
| Acetaminophen SCHEMBL2267074 | 0.90 | MAPT (0.80) | KMT2AALDH1A1MAPTMEN1CA1 | |
| Acetaminophen SCHEMBL10325382 | 0.89 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA1 | |
| Acetaminophen SCHEMBL8207526 | 0.89 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA1 | |
| Acetaminophen SCHEMBL8959271 | 0.89 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA1 | |
| Acetaminophen SCHEMBL20541508 | 0.89 | ALDH1A1 (0.95) | KMT2AALDH1A1MAPTMEN1CA1 | |
| Acetaminophen SCHEMBL8197085 | 0.89 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA1 | |
| Acetaminophen SCHEMBL5081499 | 0.89 | KMT2A (0.95) | KMT2AALDH1A1MAPTMEN1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140066516-A1 | Novel Method | GlaxoSmithKline, LLC (US) | 2014-03-06 | — | — | US | disclosed |
| US-8604084-B2 | Method | GlaxoSmithKline, LLC (US) | 2013-12-10 | — | — | US | disclosed |
| US-20110301243-A1 | NOVEL METHOD | GLAXOSMITHKLINE LLC | 2011-12-08 | — | — | US | disclosed |
| CN-102170782-A | Novel method | SMITHKLINE BEECHAM CORP | 2011-08-31 | — | — | CN | disclosed |
| EP-2309852-A1 | NOVEL METHOD | GlaxoSmithKline LLC (US) | 2011-04-20 | — | — | EP | disclosed |
| WO-2010014661-A1 | NOVEL METHOD | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-04 | — | — | WO | disclosed |