Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CLK3 | P49761 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNK | O75909 | 2/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15343201 | 0.89 | PIK3CA (0.41) | SYKTBK1DYRK1AGSK3BTDO2 | |
| SCHEMBL15473155 | 0.86 | FLT3 (0.46) | SYKTBK1HRH4FLT3TYRO3 | |
| SCHEMBL16665019 | 0.86 | TDO2 (0.44) | SYKTBK1TDO2CCNKCDK12 | |
| SCHEMBL15473174 | 0.86 | TDO2 (0.46) | SYKTBK1DYRK1AGSK3BTDO2 | |
| SCHEMBL15473069 | 0.81 | TBK1 (0.40) | SYKTBK1HRH4DYRK1AGSK3B | |
| SCHEMBL19355355 | 0.81 | CYP1A2 (0.47) | SYKHRH4GSK3BFLT3TYRO3 | |
| SCHEMBL15356477 | 0.80 | KIT (0.50) | PIK3CA | |
| SCHEMBL15356381 | 0.80 | ALDH1A1 (0.41) | SYKTBK1DYRK1AGSK3BPIK3CA | |
| SCHEMBL20373137 | 0.80 | CYP3A4 (0.42) | SYKDYRK1AGSK3BFLT3TYRO3 | |
| SCHEMBL17634517 | 0.80 | CYP3A4 (0.42) | SYKDYRK1AGSK3BFLT3TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015058031-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-04-23 | — | — | WO | disclosed |