Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.42 |
| ▸ | FAAH | O00519 | 6/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29239986 | 0.86 | PTPN7 (0.40) | FAAHPNMTPDE2ATRPV1 | |
| SCHEMBL29239988 | 0.86 | PTPN7 (0.40) | FAAHPNMTPDE2ATRPV1 | |
| SCHEMBL18290662 | 0.83 | PDE2A (0.49) | KIF11FAAHFFAR1PDE2ATRPV1 | |
| SCHEMBL12497282 | 0.81 | SLC7A5 (0.43) | KIF11FAAHFFAR1PNMTSLC7A5 | |
| SCHEMBL8130819 | 0.80 | CES2 (0.46) | FAAH | |
| SCHEMBL28196899 | 0.79 | ADRA2A (0.60) | FAAH | |
| SCHEMBL28196898 | 0.79 | ADRA2A (0.60) | FAAH | |
| SCHEMBL12498064 | 0.79 | KIF11 (0.43) | KIF11FAAHFFAR1TRPM8PDE2A | |
| SCHEMBL12498061 | 0.79 | KIF11 (0.43) | KIF11FAAHFFAR1TRPM8PDE2A | |
| SCHEMBL703244 | 0.77 | KIF11 (0.46) | KIF11FFAR1PDE2ATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133187-B2 | Serine/threonine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2015-09-15 | — | — | US | disclosed |
| US-9133187-B2 | Serine/threonine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2015-09-15 | — | — | US | disclosed |
| EP-2681215-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-04-22 | — | — | EP | disclosed |