Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 7/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.52 |
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | DBH | P09172 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1666376 | 0.89 | TLR8 (0.48) | TLR8LMNACYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL1666047 | 0.87 | TLR8 (0.54) | TLR8MAPK1MEN1KMT2ADBH | |
| Hydrochloric Acid SCHEMBL1665754 | 0.86 | TLR8 (0.48) | TLR8MEN1KMT2ADBH | |
| SCHEMBL5051627 | 0.84 | ATR (0.47) | TLR8MAPK1USP2ALOX15MEN1 | |
| SCHEMBL5053775 | 0.83 | TLR8 (0.50) | TLR8MAPK1MEN1KMT2ADBH | |
| SCHEMBL1666611 | 0.83 | KEAP1 (0.48) | TLR8CYP1A2CYP3A4CYP2C19CYP2C9 | |
| Hydrochloric Acid SCHEMBL1666211 | 0.83 | TLR8 (0.50) | TLR8MAPK1ADORA1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1666361 | 0.82 | TLR8 (0.52) | TLR8MAPK1MEN1KMT2ADBH | |
| SCHEMBL1666165 | 0.82 | TLR8 (0.53) | TLR8MAPK1MEN1KMT2ADBH | |
| SCHEMBL1668543 | 0.82 | TLR8 (0.51) | TLR8LMNATSHRMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921406-B2 | 5-ring heteroaromatic compounds and their use as binding partners for 5-HT5 receptors | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-12-30 | — | — | US | claimed |
| US-20150183770-A1 | 5-RING HETEROAROMATIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBVIE DEUTSCHLAND (DE) | 2015-07-02 | — | — | US | disclosed |
| US-8921406-B2 | 5-ring heteroaromatic compounds and their use as binding partners for 5-HT5 receptors | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-12-30 | — | — | US | disclosed |
| EP-1917251-B1 | 5-RING HETEROAROMATIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBOTT GMBH & CO KG (DE) | 2013-04-03 | — | — | EP | disclosed |
| US-20110207788-A1 | 5-Ring Heteroaromatic compounds and their use as binding partners for 5-ht5 receptors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2011-08-25 | — | — | US | disclosed |
| EP-2308852-A1 | 5-ring heteroaromatic compounds and their use as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-04-13 | — | — | EP | disclosed |
| EP-1917251-A2 | 5-RING HETEROAROMATIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | Abbott GmbH & Co. KG (DE) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007022947-A2 | 5-RING HETEROAROMATIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBOTT GMBH & CO. KG (DE) | 2007-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150183770-A1 | 5-RING HETEROAROMATIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | HTR5A, HTR3A, HTR6 | TLR8 3449/4885LMNA 3754/4885CYP1A2 613/4885 |
| US-20110207788-A1 | 5-Ring Heteroaromatic compounds and their use as binding partners for 5-ht5 receptors | HTR5A, HTR3A, HTR6 | TLR8 3449/4885LMNA 3754/4885CYP1A2 613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.