Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 5/20 | 0.57 |
| ▸ | BRAF | P15056 | 1/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.57 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.57 |
| ▸ | FLT1 | P17948 | 3/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | XBP1 | P17861 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19688778 | 0.88 | MGLL (0.76) | MGLLRXFP1MAPTMEN1GAA | |
| SCHEMBL13528827 | 0.80 | MAPK14 (0.73) | KDRBRAFMAPK14TNNI3KABL1 | |
| SCHEMBL1334862 | 0.80 | POLB (0.88) | MGLLPOLBMAPTNAMPTSMN1; SMN2 | |
| SCHEMBL19745427 | 0.79 | ALDH1A1 (0.56) | MGLLMAPTMEN1GAAXBP1 | |
| SCHEMBL2094340 | 0.79 | MAPT (0.61) | MGLLMAPTMEN1GAAXBP1 | |
| SCHEMBL7565660 | 0.79 | SMN1; SMN2 (0.62) | POLBMAPTMEN1GAAXBP1 | |
| SCHEMBL11616056 | 0.79 | NAMPT (0.74) | KDRBRAFMAPK14TNNI3KFLT1 | |
| SCHEMBL1665485 | 0.78 | POLB (0.84) | MGLLPOLBMAPTMEN1KMT2A | |
| SCHEMBL3174300 | 0.78 | KDR (0.70) | POLBKDRBRAFMAPK14TNNI3K | |
| SCHEMBL19745670 | 0.78 | HDAC1 (0.58) | MGLLMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313094-A1 | NEW PYRIDINE DERIVATIVES AS LEPTIN RECEPTOR MODULATOR MIMETICS | AstraZeneca AB (SE) | 2011-04-27 | — | — | EP | claimed |
| WO-2009147216-A1 | NEW PYRIDINE DERIVATIVES AS LEPTIN RECEPTOR MODULATOR MIMETICS | BIOVITRUM AB (PUBL) (SE) | 2009-12-10 | — | — | WO | claimed |
| EP-2313094-A1 | NEW PYRIDINE DERIVATIVES AS LEPTIN RECEPTOR MODULATOR MIMETICS | AstraZeneca AB (SE) | 2011-04-27 | — | — | EP | disclosed |
| WO-2009147216-A1 | NEW PYRIDINE DERIVATIVES AS LEPTIN RECEPTOR MODULATOR MIMETICS | BIOVITRUM AB (PUBL) (SE) | 2009-12-10 | — | — | WO | disclosed |