Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | ACHE | P22303 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | HRH2 | P25021 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10282549 | 0.86 | ACHE (0.72) | POLBACHEALDH1A1SMN1; SMN2HTT | |
| SCHEMBL15134834 | 0.86 | POLB (0.68) | POLBACHEALDH1A1MEN1KMT2A | |
| SCHEMBL335348 | 0.85 | RAB9A (0.66) | POLBALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL4377393 | 0.85 | MAPK1 (0.54) | POLBALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL10282350 | 0.84 | POLB (0.69) | POLBACHEALDH1A1MEN1KMT2A | |
| SCHEMBL10282611 | 0.84 | ALDH1A1 (0.74) | POLBACHEALDH1A1MEN1KMT2A | |
| SCHEMBL15650734 | 0.84 | POLB (0.61) | POLBACHEALDH1A1MEN1KMT2A | |
| SCHEMBL5061523 | 0.83 | ALDH1A1 (0.64) | POLBACHEALDH1A1MEN1KMT2A | |
| SCHEMBL5055842 | 0.82 | LMNA (0.66) | POLBALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL10244937 | 0.82 | NPC1 (0.57) | POLBALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405973-B1 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | UNIV LEUVEN KATH (BE) | 2015-04-22 | — | — | EP | disclosed |