⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17040215 | 0.74 | — | — | |
| SCHEMBL506099 | 0.70 | DNMT1 (0.39) | — | |
| SCHEMBL12702629 | 0.68 | ALDH1A1 (0.44) | — | |
| SCHEMBL20402394 | 0.67 | ADORA2A (0.46) | — | |
| SCHEMBL5694084 | 0.67 | DNMT1 (0.37) | — | |
| SCHEMBL10059382 | 0.66 | XDH (0.49) | — | |
| SCHEMBL18934389 | 0.65 | DNMT1 (0.38) | — | |
| SCHEMBL1836382 | 0.65 | DNMT1 (0.41) | — | |
| SCHEMBL11052944 | 0.62 | CRHR1 (0.38) | — | |
| SCHEMBL1705027 | 0.60 | CDK1 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110746476-A | 5-azacytosine nucleoside compound and preparation method thereof | 江苏豪森药业集团有限公司 | 2020-02-04 | — | — | CN | disclosed |
| US-9109000-B2 | Synthesis of nucleosides | FARMABIOS, S.p.A. (IT) | 2015-08-18 | — | — | US | disclosed |
| US-20140135490-A1 | SYNTHESIS OF NUCLEOSIDES | FARMABIOS S.P.A. (IT) | 2014-05-15 | — | — | US | disclosed |
| EP-2318423-B1 | PROCESS FOR MAKING 5-AZACYTOSINE NUCLEOSIDES AND THEIR DERIVATIVES | SCINOPHARM TAIWAN LTD (TW) | 2014-05-07 | — | — | EP | disclosed |
| US-8586729-B2 | Synthesis of decitabine | SCINOPHARM TAIWAN LTD. (TW) | 2013-11-19 | — | — | US | disclosed |
| EP-2341772-B1 | SYNTHESIS OF DECITABINE | SCINOPHARM TAIWAN LTD (TW) | 2013-04-17 | — | — | EP | disclosed |
| EP-2483250-A1 | SYNTHESIS OF DECITABINE | ScinoPharm Taiwan, Ltd. (TW) | 2012-08-08 | — | — | EP | disclosed |
| US-8212021-B2 | Process for making 5-azacytosine nucleosides and their derivatives | SCINOPHARM TAIWAN, LTD. (TW) | 2012-07-03 | — | — | US | disclosed |
| EP-2341772-A1 | SYNTHESIS OF DECITABINE | ScinoPharm Taiwan, Ltd. (TW) | 2011-07-13 | — | — | EP | disclosed |
| EP-2318423-A1 | PROCESS FOR MAKING 5-AZACYTOSINE NUCLEOSIDES AND THEIR DERIVATIVES | Scinopharm Taiwan, Ldt. (TW) | 2011-05-11 | — | — | EP | disclosed |
| WO-2011040984-A1 | SYNTHESIS OF DECITABINE | SCINOPHARM TAIWAN LTD. (TW) | 2011-04-07 | — | — | WO | disclosed |
| WO-2010040056-A1 | SYNTHESIS OF DECITABINE | SCINOPHARM TAIWAN LTD. (TW) | 2010-04-08 | — | — | WO | disclosed |
| US-20100087637-A1 | Synthesis of Decitabine | SCINOPHARM TAIWAN LTD. | 2010-04-08 | — | — | US | disclosed |
| WO-2010017547-A1 | PROCESS FOR MAKING 5-AZACYTOSINE NUCLEOSIDES AND THEIR DERIVATIVES | SCINOPHARM TAIWAN LDT. (TW) | 2010-02-11 | — | — | WO | disclosed |
| US-20100036112-A1 | Process for Making 5-Azacytosine Nucleosides and Their Derivatives | SCINOPHARM TAIWAN LTD. | 2010-02-11 | — | — | US | disclosed |