Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17040215 | 0.71 | — | — | |
| SCHEMBL1666675 | 0.70 | — | — | |
| SCHEMBL12724275 | 0.69 | CDK1 (0.47) | DNMT1GMNNALDH1A1LMNATP53 | |
| SCHEMBL12702629 | 0.69 | ALDH1A1 (0.44) | DNMT1GMNNALDH1A1LMNATP53 | |
| SCHEMBL12451367 | 0.69 | CDK1 (0.47) | DNMT1GMNNALDH1A1LMNATP53 | |
| SCHEMBL5694084 | 0.68 | DNMT1 (0.37) | DNMT1GMNNALDH1A1LMNATP53 | |
| SCHEMBL28384782 | 0.67 | KDM4E (0.40) | ALDH1A1MTOR | |
| SCHEMBL8080123 | 0.67 | LMNA (0.39) | ALDH1A1LMNAMTOR | |
| SCHEMBL20402394 | 0.64 | ADORA2A (0.46) | DNMT1GMNNALDH1A1LMNATP53 | |
| SCHEMBL11052944 | 0.63 | CRHR1 (0.38) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120029181-A1 | SYNTHESIS OF 5-AZACYTIDINE | PHARMION LLC (US) | 2012-02-02 | — | — | US | disclosed |
| US-8058424-B2 | Synthesis of 5-azacytidine | PHARMION LLC (US) | 2011-11-15 | — | — | US | disclosed |
| US-20110092694-A1 | SYNTHESIS OF 5-AZACYTIDINE | PHARMION LLC | 2011-04-21 | — | — | US | disclosed |
| US-7858774-B2 | Coupling silylated 5-azacytosine to a protected ribofuranose using trimethylsilyl trifluoromethane catalyst; cooling, accumulation by filtration, quenching, solvent extraction | PHARMION LLC (US) | 2010-12-28 | — | — | US | disclosed |
| US-20090005551-A1 | SYNTHESIS OF 5-AZACYTIDINE | CELGENE INTERNATIONAL SARL (CH) | 2009-01-01 | — | — | US | disclosed |
| US-20060247432-A1 | Synthesis of 5-Azacytidine | CELGENE INTERNATIONAL SARL (CH) | 2006-11-02 | — | — | US | disclosed |
| US-7038038-B2 | Synthesis of 5-azacytidine | PHARMION CORPORATION (US) | 2006-05-02 | — | — | US | disclosed |
| WO-2004082618-A2 | SYNTHESIS OF 5-AZACYTIDINE | ASH STEVENS INC (US) | 2004-09-30 | — | — | WO | disclosed |
| US-20040186283-A1 | Synthesis of 5-azacytidine | CELGENE INTERNATIONAL SARL (CH) | 2004-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092694-A1 | SYNTHESIS OF 5-AZACYTIDINE | TYMS, DNMT1, TET1 | DNMT1 2/4885GMNN 114/4885ALDH1A1 2154/4885 |
| US-20120029181-A1 | SYNTHESIS OF 5-AZACYTIDINE | TYMS, DNMT1, TET1 | DNMT1 2/4885GMNN 114/4885ALDH1A1 2154/4885 |
| US-20060247432-A1 | Synthesis of 5-Azacytidine | TYMS, DNMT1, TET1 | DNMT1 2/4885GMNN 114/4885ALDH1A1 2154/4885 |
| US-20040186283-A1 | Synthesis of 5-azacytidine | DNMT1, TYMS, TET1 | DNMT1 1/4885GMNN 123/4885ALDH1A1 2092/4885 |
| US-20090005551-A1 | SYNTHESIS OF 5-AZACYTIDINE | TYMS, DNMT1, TET1 | DNMT1 2/4885GMNN 114/4885ALDH1A1 2154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.