Sugi Predict

Sugi Predict / Compounds / SCHEMBL16670002

SCHEMBL16670002

SCHEMBL16670002

CN(C(=O)OC(C)(C)C)c1ccc2cc(C(=O)O)ccc2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 1/20 0.46
▸ PAX8 Q06710 1/20 0.45
▸ RARB P10826 3/20 0.42
▸ RARG P13631 3/20 0.42
▸ RARA P10276 2/20 0.42
▸ BRD4 O60885 1/20 0.40
▸ PLAU P00749 1/20 0.38
▸ RAB9A P51151 2/20 0.38
▸ NPC1 O15118 2/20 0.38
▸ PTPN1 P18031 1/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ MEN1 O00255 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ NPSR1 Q6W5P4 1/20 0.37
▸ TDP1 Q9NUW8 1/20 0.36
▸ GABRB1 P18505 1/20 0.36
▸ GABRB2 P47870 1/20 0.36
▸ GRIN2D O15399 1/20 0.36
▸ GRIN2A Q12879 1/20 0.36
▸ GRIN2B Q13224 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16682552 0.89 RAB9A (0.43) KDM4EPAX8BRD4PLAURAB9A
SCHEMBL846595 0.85 PAX8 (0.51) PAX8BRD4RAB9ANPC1SMN1; SMN2
SCHEMBL31453143 0.84 PAX8 (0.51) KDM4EPAX8BRD4RAB9ANPC1
SCHEMBL1401093 0.82 BRD4 (0.50) PAX8BRD4RAB9ANPC1SMN1; SMN2
SCHEMBL29909826 0.82 BRD4 (0.50) PAX8BRD4RAB9ANPC1SMN1; SMN2
SCHEMBL14715354 0.81 PAX8 (0.54) PAX8BRD4RAB9ANPC1SMN1; SMN2
SCHEMBL23535828 0.80 KDM4E (0.41) KDM4EPAX8RARBRARGRARA
SCHEMBL31504563 0.80 KDM4E (0.41) KDM4EPAX8RARBRARGRARA
SCHEMBL15597297 0.79 PAX8 (0.44) PAX8BRD4RAB9AMEN1KMT2A
SCHEMBL30339105 0.78 RXRB (0.42) PAX8RARBBRD4RAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160022642-A1 Compounds Useful for Promoting Protein Degradation and Methods Using Same YALE UNIVERSITY 2016-01-28 — — US disclosed
US-20160022642-A1 Compounds Useful for Promoting Protein Degradation and Methods Using Same YALE UNIVERSITY 2016-01-28 — — US disclosed
US-20160022642-A1 Compounds Useful for Promoting Protein Degradation and Methods Using Same YALE UNIVERSITY 2016-01-28 — — US disclosed
US-20150119435-A1 COMPOUNDS USEFUL FOR PROMOTING PROTEIN DEGRADATION AND METHODS USING SAME YALE UNIVERSITY 2015-04-30 — — US disclosed
US-20150119435-A1 COMPOUNDS USEFUL FOR PROMOTING PROTEIN DEGRADATION AND METHODS USING SAME YALE UNIVERSITY 2015-04-30 — — US disclosed
US-20150119435-A1 COMPOUNDS USEFUL FOR PROMOTING PROTEIN DEGRADATION AND METHODS USING SAME YALE UNIVERSITY 2015-04-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150119435-A1 COMPOUNDS USEFUL FOR PROMOTING PROTEIN DEGRADATION AND METHODS USING SAME PSMG3, ERAP1, SMURF2 KDM4E 833/4885PAX8 4496/4885RARB 3828/4885
US-20160022642-A1 Compounds Useful for Promoting Protein Degradation and Methods Using Same AR, SHBG, PSMG3 KDM4E 1922/4885PAX8 3743/4885RARB 1524/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.