Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 5/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025613 | 1.00 | KCNN4 (0.50) | KCNN4KIF11CYP2D6CYP1A2MAPK1 | |
| SCHEMBL2160833 | 0.77 | KCNN4 (0.50) | KCNN4KIF11CYP2D6CYP1A2MAPK1 | |
| SCHEMBL4495324 | 0.77 | KCNN4 (0.50) | KCNN4KIF11CYP2D6CYP1A2CHRM2 | |
| SCHEMBL10675289 | 0.77 | KCNN4 (0.50) | KCNN4KIF11CYP2D6CYP1A2MAPK1 | |
| SCHEMBL2771122 | 0.75 | CYP1A2 (0.40) | KCNN4KIF11CYP2D6CYP1A2ALDH1A1 | |
| SCHEMBL19381442 | 0.74 | KCNN4 (0.46) | KCNN4KIF11CYP2D6CYP1A2TDP1 | |
| SCHEMBL16609226 | 0.74 | KCNN4 (0.52) | KCNN4KIF11TDP1CACNA1FCHRM2 | |
| SCHEMBL6566499 | 0.74 | KCNN4 (0.52) | KCNN4KIF11TDP1CACNA1FCHRM2 | |
| SCHEMBL7556522 | 0.74 | KCNN4 (0.46) | KCNN4KIF11CYP2D6CYP1A2MAPK1 | |
| SCHEMBL2552806 | 0.72 | KCNN4 (0.45) | KCNN4KIF11CYP2D6CYP1A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105764909-B | stable pantetheine derivatives for the treatment of pantothenate kinase-associated neurodegeneration (PKAN) and methods for synthesizing such compounds | 阿西耶斯生物公司 | 2019-12-06 | — | — | CN | disclosed |
| EP-3066106-B1 | STABLE PANTETHEINE DERIVATIVES FOR THE TREATMENT OF PANTOTHENATE KINASE ASSOCIATED NEURODEGENERATION (PKAN) AND METHODS FOR THE SYNTHESIS OF SUCH COMPOUNDS | ACIES BIO D O O (SI) | 2019-08-14 | — | — | EP | disclosed |
| US-9963472-B2 | Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (PKAN) and methods for the synthesis of such compounds | ACIES BIO D.O.O. (SI) | 2018-05-08 | — | — | US | disclosed |
| US-20180118767-A1 | STABLE PANTETHEINE DERIVATIVES FOR THE TREATMENT OF PANTOTHENATE KINASE ASSOCIATED NEURODEGENERATION (PKAN) AND METHODS FOR THE SYNTHESIS OF SUCH COMPOUNDS | COMET THERAPEUTICS B.V. (NL) | 2018-05-03 | — | — | US | disclosed |
| US-20160297840-A1 | STABLE PANTETHEINE DERIVATIVES FOR THE TREATMENT OF PANTOTHENATE KINASE ASSOCIATED NEURODEGENERATION (PKAN) AND METHODS FOR THE SYNTHESIS OF SUCH COMPOUNDS | VECTIVBIO COMET AG, F/K/A COMET THERAPEUTICS, INC. (CH) | 2016-10-13 | — | — | US | disclosed |
| EP-3066106-A1 | STABLE PANTETHEINE DERIVATIVES FOR THE TREATMENT OF PANTOTHENATE KINASE ASSOCIATED NEURODEGENERATION (PKAN) AND METHODS FOR THE SYNTHESIS OF SUCH COMPOUNDS | Acies Bio d.o.o. (SI) | 2016-09-14 | — | — | EP | disclosed |
| WO-2015063177-A1 | STABLE PANTETHEINE DERIVATIVES FOR THE TREATMENT OF PANTOTHENATE KINASE ASSOCIATED NEURODEGENERATION (PKAN) AND METHODS FOR THE SYNTHESIS OF SUCH COMPOUNDS | ACIES BIO D.O.O. (SI) | 2015-05-07 | — | — | WO | disclosed |
| EP-2868662-A1 | Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (pkan) and methods for the synthesis of such compounds | Acies Bio d.o.o. (SI) | 2015-05-06 | — | — | EP | disclosed |
| US-20140107135-A1 | PYRIMIDINONE INHIBITORS OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2014-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118767-A1 | STABLE PANTETHEINE DERIVATIVES FOR THE TREATMENT OF PANTOTHENATE KINASE ASSOCIATED NEURODEGENERATION (PKAN) AND METHODS FOR THE SYNTHESIS OF SUCH COMPOUNDS | PANK3, PANK1, PANK2 | KCNN4 2577/4885KIF11 2552/4885CYP2D6 3979/4885 |
| US-20140107135-A1 | PYRIMIDINONE INHIBITORS OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 | PLA2G1B, PLA2G4A, PLA2G4B | KCNN4 4626/4885KIF11 4738/4885CYP2D6 1842/4885 |
| US-20160297840-A1 | STABLE PANTETHEINE DERIVATIVES FOR THE TREATMENT OF PANTOTHENATE KINASE ASSOCIATED NEURODEGENERATION (PKAN) AND METHODS FOR THE SYNTHESIS OF SUCH COMPOUNDS | PANK3, PANK1, PANK2 | KCNN4 2577/4885KIF11 2552/4885CYP2D6 3979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.