Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | VCP | P55072 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12027633 | 0.85 | MCHR1 (0.47) | GPR119BRD4HCRTR1HCRTR2 | |
| SCHEMBL24289285 | 0.82 | GPR119 (0.50) | GPR119HCRTR1HCRTR2VCPNR1H2 | |
| SCHEMBL1112019 | 0.80 | MAPT (0.46) | GPR119BRD4HCRTR1HCRTR2MAPT | |
| SCHEMBL23961145 | 0.79 | MAPT (0.48) | MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL1540032 | 0.76 | HDAC3 (0.49) | GPR119LMNAHCRTR1HCRTR2MAPT | |
| SCHEMBL1540031 | 0.76 | MAPT (0.43) | GPR119LMNAHCRTR1HCRTR2MAPT | |
| SCHEMBL12279845 | 0.76 | ALDH1A1 (0.53) | GPR119LMNAMAPTTSHRALDH1A1 | |
| SCHEMBL16675746 | 0.76 | PDK2 (0.42) | LMNAMAPTTSHRALDH1A1NOTUM | |
| SCHEMBL29029431 | 0.75 | HDAC3 (0.56) | LMNABRD4CREBBPHCRTR1HCRTR2 | |
| SCHEMBL29478358 | 0.74 | ALDH1A1 (0.60) | BRD4MAPTALDH1A1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188251-B1 | ARYLSULFONAMIDES WITH ANALGESIC ACTIVITY | BOEHRINGER INGELHEIM INT (DE) | 2015-04-29 | — | — | EP | disclosed |