Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.40 |
| ▸ | PDE1A | P54750 | 2/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 3/20 | 0.38 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RXFP3 | Q9NSD7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6949006 | 0.89 | SMN1; SMN2 (0.40) | ALDH1A1L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL5134079 | 0.84 | HPGD (0.39) | ALDH1A1L3MBTL1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL5053350 | 0.82 | PDE10A (0.44) | PDE10APDE1BPDE1APDE1CHTR6 | |
| SCHEMBL1664866 | 0.72 | CNR2 (0.40) | ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL6952421 | 0.72 | NR3C1 (0.42) | ALDH1A1L3MBTL1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL5062834 | 0.72 | TLR7 (0.41) | ALDH1A1L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL1665092 | 0.72 | CTSL (0.39) | SMN1; SMN2 | |
| SCHEMBL2333112 | 0.71 | TNF (0.30) | ALDH1A1LMNA | |
| SCHEMBL22438726 | 0.71 | DCTPP1 (0.54) | PDE10APDE1BPDE1APDE1CALDH1A1 | |
| SCHEMBL1667346 | 0.70 | CNR2 (0.41) | PDE1BALDH1A1L3MBTL1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2308870-A2 | 2-oxo-1-pyrrolidine deriatives, processes for preparing them and their uses | UCB Pharma S.A. (BE) | 2011-04-13 | — | — | EP | disclosed |