Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | HPGD | P15428 | 6/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.53 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.53 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527356 | 0.84 | RAB9A (0.69) | RAB9ASMN1; SMN2KMT2AHPGDFKBP1A | |
| SCHEMBL9529304 | 0.84 | RAB9A (0.97) | RAB9ASMN1; SMN2KMT2AHPGDFKBP1A | |
| SCHEMBL12503286 | 0.83 | FKBP1A (0.71) | RAB9ASMN1; SMN2KMT2AHPGDFKBP1A | |
| SCHEMBL24814445 | 0.78 | FKBP1A (0.49) | RAB9ASMN1; SMN2KMT2AHPGDFKBP1A | |
| SCHEMBL29986456 | 0.78 | FKBP1A (0.49) | RAB9ASMN1; SMN2KMT2AHPGDFKBP1A | |
| SCHEMBL16679379 | 0.74 | RAB9A (0.52) | RAB9ASMN1; SMN2KMT2AHPGDUSP2 | |
| Hydrochloric Acid SCHEMBL20767837 | 0.73 | RAB9A (0.51) | RAB9ASMN1; SMN2KMT2AHPGDUSP2 | |
| SCHEMBL24564850 | 0.73 | SIGMAR1 (0.54) | SMN1; SMN2KMT2AHPGDFKBP1AALDH1A1 | |
| SCHEMBL16679378 | 0.73 | RAB9A (0.54) | RAB9ASMN1; SMN2KMT2AHPGDFKBP1A | |
| SCHEMBL1883404 | 0.73 | SMN1; SMN2 (0.67) | SMN1; SMN2KMT2AHPGDALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190144464-A1 | BIGUANIDE COMPOUNDS AND USE THEREOF | HANALL BIOPHARMA CO., LTD. (KR) | 2019-05-16 | — | — | US | disclosed |
| US-10221190-B2 | Biguanide compounds and use thereof | IMMUNOMET THERAPEUTICS INC. (US) | 2019-03-05 | — | — | US | disclosed |
| US-20150126518-A1 | BIGUANIDE COMPOUNDS AND USE THEREOF | HANALL BIOPHARMA CO., LTD. (KR) | 2015-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144464-A1 | BIGUANIDE COMPOUNDS AND USE THEREOF | GCKR, GCG, SLC5A2 | RAB9A 1910/4885SMN1; SMN2 3490/4885KMT2A 3654/4885 |
| US-20150126518-A1 | BIGUANIDE COMPOUNDS AND USE THEREOF | GCKR, GCG, SLC5A2 | RAB9A 1910/4885SMN1; SMN2 3490/4885KMT2A 3654/4885 |
| US-10221190-B2 | Biguanide compounds and use thereof | GCKR, GCG, SLC5A2 | RAB9A 1910/4885SMN1; SMN2 3490/4885KMT2A 3654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.