Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 13/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 12/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 10/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | EBPL | Q9BY08 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1670735 | 0.90 | CHRM5 (0.46) | CHRM5CHRM1CHRM3SIGMAR1 | |
| SCHEMBL12801191 | 0.89 | CHRM5 (0.46) | CHRM5CHRM1CHRM3SLC22A1SLC6A4 | |
| SCHEMBL1668671 | 0.84 | FFAR4 (0.44) | CHRM5CHRM1CHRM3 | |
| SCHEMBL1668720 | 0.83 | CHRM5 (0.43) | CHRM5CHRM1CHRM3SLC22A1SLC6A4 | |
| SCHEMBL12800795 | 0.83 | CHRM5 (0.45) | CHRM5CHRM1CHRM3SIGMAR1SLC22A1 | |
| SCHEMBL1668281 | 0.81 | CHRM5 (0.39) | CHRM5CHRM1CHRM3SIGMAR1ADRA1A | |
| SCHEMBL12800404 | 0.80 | CHRM5 (0.40) | CHRM5CHRM1CHRM3OPRM1 | |
| SCHEMBL12801208 | 0.80 | FFAR4 (0.47) | CHRM5CHRM1CHRM3SIGMAR1 | |
| SCHEMBL1668325 | 0.79 | OPRM1 (0.42) | CHRM5CHRM1CHRM3OPRM1OPRD1 | |
| SCHEMBL1668476 | 0.78 | CYP2D6 (0.46) | CHRM5CHRM1CHRM3OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011048409-A1 | CYCLIC AMINE DERIVATIVES HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY | ASTRAZENECA AB (SE) | 2011-04-28 | — | — | WO | disclosed |
| WO-2011048409-A1 | CYCLIC AMINE DERIVATIVES HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY | ASTRAZENECA AB (SE) | 2011-04-28 | — | — | WO | disclosed |