Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | F12 | P00748 | 1/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | C1S | P09871 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL2241002 | 0.97 | F2 (0.44) | F2F10F12F7F3 | |
| SCHEMBL19608218 | 0.81 | PRSS1 (0.58) | PRSS1PRSS2PRSS3MAPTHDAC8 | |
| SCHEMBL24761126 | 0.75 | F2 (0.42) | F2F10F12F7F3 | |
| SCHEMBL1981632 | 0.75 | MAPT (0.48) | KMT2AMEN1CA1CA2ALDH1A1 | |
| SCHEMBL13933397 | 0.75 | LMNA (0.48) | KMT2AMEN1CA1CA2ALDH1A1 | |
| SCHEMBL8388749 | 0.75 | — | — | |
| SCHEMBL12127801 | 0.75 | HDAC8 (0.50) | KMT2AMEN1MAPTRAB9ANPC1 | |
| SCHEMBL15219042 | 0.74 | F2 (0.52) | F2F10F12F7F3 | |
| SCHEMBL2221846 | 0.73 | C1S (0.57) | KMT2AMEN1C1SALDH1A1MAPT | |
| SCHEMBL90851 | 0.73 | PARP1 (0.47) | PKMKMT2AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005385-B1 | PIPERAZINE METHANE IMINE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR THERAPEUTICAL USE | LAROCHE NAVARRON S.A. Société dite: (FR) | 1982-09-01 | — | — | EP | claimed |
| US-20170217958-A1 | PYRAZOLE DERIVATIVE MANUFACTURING METHOD | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2017-08-03 | — | — | US | disclosed |
| US-20170217958-A1 | PYRAZOLE DERIVATIVE MANUFACTURING METHOD | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2017-08-03 | — | — | US | disclosed |
| US-9550757-B2 | Nuclear transport modulators and uses thereof | Karyopharm Therapeutics Inc. (US) | 2017-01-24 | — | — | US | disclosed |
| US-9550757-B2 | Nuclear transport modulators and uses thereof | Karyopharm Therapeutics Inc. (US) | 2017-01-24 | — | — | US | disclosed |
| US-20160376266-A1 | ANTI-ALPHAVBETA1 INTEGRIN COMPOUNDS AND METHODS | UNIV CALIFORNIA (US) | 2016-12-29 | — | — | US | disclosed |
| US-9303000-B2 | Olefin containing nuclear transport modulators and uses thereof | Karyopharm Therapeutics Inc. (US) | 2016-04-05 | — | — | US | disclosed |
| EP-2590655-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2015-06-24 | — | — | EP | disclosed |
| WO-2015048819-A1 | ANTI-ALPHAVBETA1 INTEGRIN COMPOUNDS AND METHODS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-04-02 | — | — | WO | disclosed |
| US-20140155370-A1 | NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | Karyopharm Therapeutics Inc. | 2014-06-05 | — | — | US | disclosed |
| WO-2009010479-A2 | HETEROCYCLIC METHYLENE PIPERIDINE DERIVATIVES AND THEIR USE | EUROSCREEN S.A. (BE) | 2009-01-22 | — | — | WO | disclosed |
| WO-2009010479-A2 | HETEROCYCLIC METHYLENE PIPERIDINE DERIVATIVES AND THEIR USE | EUROSCREEN S.A. (BE) | 2009-01-22 | — | — | WO | disclosed |
| EP-1917251-A2 | 5-RING HETEROAROMATIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | Abbott GmbH & Co. KG (DE) | 2008-05-07 | — | — | EP | disclosed |
| US-7202243-B2 | Substituted imidazotriazines | BAYER HEALTHCARE AG (DE) | 2007-04-10 | — | — | US | disclosed |
| US-7202243-B2 | Substituted imidazotriazines | BAYER HEALTHCARE AG (DE) | 2007-04-10 | — | — | US | disclosed |
| WO-2007022947-A2 | 5-RING HETEROAROMATIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBOTT GMBH & CO. KG (DE) | 2007-03-01 | — | — | WO | disclosed |
| WO-2005118584-A2 | SAFRAMYCIN ANALOGS AS THERAPEUTIC AGENTS IN THE TREATMENT OF CANCER | AXYS PHARMACEUTICALS, INC. (US) | 2005-12-15 | — | — | WO | disclosed |
| WO-2003060191-A2 | NON-TOXIC CORROSION-PROTECTION CONVERSION COATINGES ABSED ON COBALT | UNIVERSITY OF DAYTON (US) | 2003-07-24 | — | — | WO | disclosed |
| WO-2001087845-A2 | N-CONTAINING HETEROCYCLIC COMPOUNDS AND THEIR USE AS 5-HT ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-22 | — | — | WO | disclosed |
| EP-0082113-A1 | 2-Aminobytyl-2-penem derivatives, process for their preparation and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1983-06-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217958-A1 | PYRAZOLE DERIVATIVE MANUFACTURING METHOD | CYP3A7, CYP2C19, CYP3A5 | F2 428/4885F10 1566/4885F12 156/4885 |
| US-20140155370-A1 | NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | XPO1, NXF1, XPOT | F2 4302/4885F10 3434/4885F12 2847/4885 |
| US-20160376266-A1 | ANTI-ALPHAVBETA1 INTEGRIN COMPOUNDS AND METHODS | ITGB1, ITGAV, ITGA1 | F2 1729/4885F10 1242/4885F12 338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.