Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28757155 | 0.83 | NOTUM (0.55) | NOTUMHDAC1HDAC6DRD2HTR1A | |
| SCHEMBL3427936 | 0.82 | HTR1A (0.53) | NOTUMDRD2DRD3HTR1ADRD4 | |
| SCHEMBL5905917 | 0.80 | NOTUM (0.47) | NOTUMDRD2DRD4HTR2CHTR2B | |
| SCHEMBL11304976 | 0.78 | HTR6 (0.62) | NOTUMHDAC1HDAC6DRD2HTR1A | |
| SCHEMBL16685030 | 0.78 | ALDH1A1 (0.42) | NOTUM | |
| SCHEMBL5905832 | 0.78 | NOTUM (0.47) | NOTUMDRD2DRD3DRD4 | |
| SCHEMBL2625801 | 0.77 | NOTUM (0.59) | NOTUMDRD2DRD3DRD1DRD5 | |
| SCHEMBL7039803 | 0.77 | NOTUM (0.50) | NOTUMHDAC1HDAC6DRD2DRD3 | |
| SCHEMBL16685120 | 0.76 | NOTUM (0.46) | NOTUMDRD2DRD3DRD4HTR2C | |
| SCHEMBL16684830 | 0.76 | KDM4E (0.41) | NOTUMDRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015066344-A1 | 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE | ARENA PHARMACEUTICALS, INC. (US) | 2015-05-07 | — | — | WO | disclosed |