Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 10/20 | 0.50 |
| ▸ | CTSS | P25774 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 3/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1669009 | 1.00 | CTSK (0.50) | CTSKCTSSALDH1A1TSHRMEN1 | |
| SCHEMBL7430204 | 0.97 | CTSK (0.52) | CTSKCTSSALDH1A1TSHRMEN1 | |
| SCHEMBL4981804 | 0.97 | CTSK (0.52) | CTSKCTSSALDH1A1TSHRMEN1 | |
| SCHEMBL4981797 | 0.97 | CTSK (0.52) | CTSKCTSSALDH1A1TSHRMEN1 | |
| SCHEMBL14150791 | 0.92 | CTSK (0.56) | CTSKCTSSALDH1A1TSHRMEN1 | |
| SCHEMBL6745774 | 0.92 | CTSK (0.56) | CTSKCTSSALDH1A1TSHRMEN1 | |
| SCHEMBL346192 | 0.89 | CTSK (0.49) | CTSKCTSSMEN1GAAKMT2A | |
| SCHEMBL21409086 | 0.89 | CTSK (0.49) | CTSKCTSSMEN1GAAKMT2A | |
| SCHEMBL9753568 | 0.89 | CTSK (0.49) | CTSKCTSSMEN1GAAKMT2A | |
| SCHEMBL6837916 | 0.89 | CTSK (0.56) | CTSKCTSSALDH1A1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921571-B2 | Pyrrolysine analogs | THE OHIO STATE UNIVERSITY (US) | 2014-12-30 | — | — | US | disclosed |
| US-20130035478-A1 | PYRROLYSINE ANALOGS | THE OHIO STATE UNIVERSITY (US) | 2013-02-07 | — | — | US | disclosed |
| WO-2011044255-A1 | PYRROLYSINE ANALOGS | THE OHIO STATE UNIVERSITY (US) | 2011-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035478-A1 | PYRROLYSINE ANALOGS | UROD, ALDH18A1, HMBS | CTSK 1285/4885CTSS 1403/4885ALDH1A1 2389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.