Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HINT1 | P49773 | 6/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | NT5E | P21589 | 2/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PNP | P00491 | 2/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16689919 | 1.00 | HINT1 (0.48) | HINT1TAAR1NT5EGSK3ARPS6KA3 | |
| SCHEMBL18061565 | 0.86 | TGM2 (0.51) | HINT1NT5ETAS1R3TAS1R1POLB | |
| SCHEMBL19644762 | 0.86 | TGM2 (0.51) | HINT1NT5ETAS1R3TAS1R1POLB | |
| SCHEMBL15788412 | 0.86 | HINT1 (0.51) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL16689916 | 0.83 | NT5E (0.45) | HINT1NT5EADORA3 | |
| SCHEMBL16690098 | 0.83 | NT5E (0.45) | HINT1NT5EADORA3 | |
| SCHEMBL16690095 | 0.83 | NT5E (0.45) | HINT1NT5EADORA3 | |
| SCHEMBL25380147 | 0.83 | ADORA2A (0.51) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL471141 | 0.83 | ADORA2A (0.51) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL20991026 | 0.83 | ADORA2A (0.51) | HINT1NT5EGSK3ARPS6KA3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015066370-A1 | D-ALANINE PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-METHYL 2'-FLUORO GUANOSINE NUCLEOSIDE COMPOUNDS FOR THE TREATMENT OF HCV | IDENIX PHARMACEUTICALS, INC. (US) | 2015-05-07 | — | — | WO | disclosed |