Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15262 | 0.93 | HTT (0.38) | POLBHTTTAAR1DHFR | |
| Ammonia Solution, Strong SCHEMBL3684772 | 0.91 | HTT (0.37) | POLBHTTDHFR | |
| SCHEMBL9361265 | 0.87 | HTT (0.35) | POLBHTTDHFR | |
| SCHEMBL9361400 | 0.86 | POLB (0.34) | POLBHTTDHFR | |
| SCHEMBL166178 | 0.84 | DHFR (0.42) | POLBHTTDHFR | |
| SCHEMBL30854914 | 0.83 | HTT (0.37) | POLBHTT | |
| SCHEMBL9365179 | 0.79 | POLB (0.33) | POLBHTT | |
| SCHEMBL9361610 | 0.79 | HTT (0.39) | POLBHTTTAAR1 | |
| SCHEMBL165023 | 0.78 | — | — | |
| SCHEMBL9362431 | 0.77 | ALDH1A1 (0.36) | POLBHTTDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638088-B1 | HALOGENATION OF 4,4'-METHYLENE-BIS-ANILINES | LONZA AG (CH) | 2015-11-18 | — | — | EP | disclosed |
| EP-2638088-A1 | HALOGENATION OF 4,4'-METHYLENE-BIS-ANILINES | Lonza Ltd (CH) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012028323-A1 | HALOGENATION OF 4,4'-METHYLENE-BIS-ANILINES | LONZA LTD (CH) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012028323-A1 | HALOGENATION OF 4,4'-METHYLENE-BIS-ANILINES | LONZA LTD (CH) | 2012-03-08 | — | — | WO | disclosed |