Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.38 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16692826 | 0.88 | TNIK (0.46) | ROCK2ROCK1TNIKKDM4EALDH1A1 | |
| SCHEMBL16692858 | 0.85 | CYP2C9 (0.43) | TNIKHCRTR1HCRTR2PIK3CDPIK3CB | |
| SCHEMBL16691340 | 0.84 | GRM5 (0.41) | TNIKALDH1A1GAA | |
| SCHEMBL16692866 | 0.79 | TNIK (0.44) | TNIKKDM4EALDH1A1LMNADRD2 | |
| SCHEMBL30443099 | 0.79 | TNIK (0.44) | TNIKKDM4EALDH1A1LMNADRD2 | |
| SCHEMBL16692848 | 0.79 | PKM (0.39) | TNIKKDM4EALDH1A1DRD2 | |
| SCHEMBL16692869 | 0.78 | CNR2 (0.44) | KDM4EALDH1A1HCRTR1HCRTR2CNR2 | |
| SCHEMBL16692842 | 0.78 | KCNH2 (0.43) | ROCK2ROCK1ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL25184831 | 0.75 | USP1 (0.43) | TNIK | |
| SCHEMBL30443641 | 0.75 | USP1 (0.43) | TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015066697-A1 | FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF | FORUM PHARMACEUTICALS INC. (US) | 2015-05-07 | — | — | WO | disclosed |