Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
| ▸ | SCN4A | P35499 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.38 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16692826 | 0.85 | TNIK (0.46) | ALDH1A1ROCK2ROCK1HCRTR2 | |
| SCHEMBL30443099 | 0.83 | TNIK (0.44) | KCNH2ALDH1A1TSHRGRM2DRD4 | |
| SCHEMBL16692866 | 0.83 | TNIK (0.44) | KCNH2ALDH1A1TSHRGRM2DRD4 | |
| SCHEMBL16692848 | 0.83 | PKM (0.39) | SCN9AALDH1A1TSHRDRD4DRD2 | |
| SCHEMBL16691340 | 0.81 | GRM5 (0.41) | SCN9AALDH1A1 | |
| SCHEMBL16692874 | 0.78 | ROCK2 (0.50) | KCNH2ALDH1A1ROCK2ROCK1KCNN3 | |
| SCHEMBL16691284 | 0.77 | PSEN1 (0.45) | — | |
| SCHEMBL16692858 | 0.76 | CYP2C9 (0.43) | KCNH2HCRTR1HCRTR2DRD2DRD3 | |
| SCHEMBL16692869 | 0.76 | CNR2 (0.44) | KCNH2ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL25184831 | 0.75 | USP1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015066697-A1 | FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF | FORUM PHARMACEUTICALS INC. (US) | 2015-05-07 | — | — | WO | disclosed |