Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 5/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | YAP1 | P46937 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12800403 | 0.94 | OPRD1 (0.46) | OPRD1OPRK1TACR1FFAR4YAP1 | |
| SCHEMBL12801209 | 0.90 | OPRD1 (0.47) | OPRD1OPRK1TACR1FFAR4YAP1 | |
| SCHEMBL1669035 | 0.88 | OPRD1 (0.39) | OPRD1OPRK1TACR1CHRM5CHRM1 | |
| SCHEMBL12800828 | 0.83 | OPRD1 (0.39) | OPRD1OPRK1TACR1FFAR4APP | |
| SCHEMBL12801201 | 0.83 | OPRD1 (0.46) | OPRD1OPRK1TACR1 | |
| SCHEMBL1668671 | 0.82 | FFAR4 (0.44) | FFAR4MTNR1AMTNR1BAPPFFAR1 | |
| SCHEMBL1671810 | 0.82 | OPRD1 (0.51) | OPRD1OPRK1TACR1YAP1 | |
| SCHEMBL16499482 | 0.81 | OPRD1 (0.46) | OPRD1OPRK1TACR1YAP1 | |
| SCHEMBL1669177 | 0.80 | OPRD1 (0.52) | OPRD1OPRK1TACR1FFAR4YAP1 | |
| SCHEMBL12801231 | 0.77 | OPRD1 (0.47) | OPRD1OPRK1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011048409-A1 | CYCLIC AMINE DERIVATIVES HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY | ASTRAZENECA AB (SE) | 2011-04-28 | — | — | WO | disclosed |