Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 9/20 | 0.38 |
| ▸ | NPC1 | O15118 | 8/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26725482 | 0.82 | HTR2C (0.56) | BACE1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL16693581 | 0.81 | BACE1 (0.48) | BACE1HDAC1RAB9ANPC1MAPT | |
| SCHEMBL16693618 | 0.78 | BACE1 (0.48) | BACE1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL26725267 | 0.74 | BACE1 (0.50) | BACE1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL16693604 | 0.74 | RAB9A (0.50) | BACE1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL20580922 | 0.72 | LMNA (0.45) | BACE1HDAC1RAB9ANPC1LMNA | |
| Hydrochloric Acid SCHEMBL20239286 | 0.71 | MEN1 (0.45) | BACE1HDAC1MAPTMEN1KMT2A | |
| SCHEMBL19313222 | 0.71 | TGM2 (0.44) | BACE1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL18313982 | 0.70 | MEN1 (0.44) | HDAC1RAB9ANPC1MAPTMEN1 | |
| SCHEMBL22824754 | 0.69 | NPC1 (0.49) | BACE1RAB9ANPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9321774-B2 | Pyrrolobenzodiazepines | MEDIMMUNE LIMITED (GB) | 2016-04-26 | — | — | US | disclosed |
| US-20150126495-A1 | PYRROLOBENZODIAZEPINES | MEDIMMUNE LIMITED (GB) | 2015-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150126495-A1 | PYRROLOBENZODIAZEPINES | CHRM1, CHRM2, CHRM3 | BACE1 3215/4885HDAC1 1240/4885RAB9A 1063/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.