Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18975726 | 0.87 | LMNA (0.40) | LMNAHDAC1SYKFLT3CLK1 | |
| SCHEMBL20581154 | 0.82 | LMNA (0.46) | LMNAHDAC1SYKFLT3MCHR1 | |
| SCHEMBL22824882 | 0.78 | HDAC1 (0.41) | HDAC1FLT3DYRK1AMEN1KMT2A | |
| SCHEMBL18313982 | 0.77 | MEN1 (0.44) | HDAC1FLT3CLK1DYRK1AMEN1 | |
| SCHEMBL18313988 | 0.76 | MEN1 (0.42) | HDAC1FLT3BACE1CLK1DYRK1A | |
| SCHEMBL16693602 | 0.72 | BACE1 (0.48) | LMNAHDAC1BACE1MEN1NPC1 | |
| SCHEMBL20581157 | 0.72 | CYP1A2 (0.47) | LMNAHDAC1FLT3MCHR1KMT2A | |
| Hydrochloric Acid SCHEMBL20239286 | 0.71 | MEN1 (0.45) | HDAC1BACE1MEN1KMT2A | |
| SCHEMBL21941140 | 0.71 | LMNA (0.42) | LMNAHDAC1SYKFLT3BACE1 | |
| SCHEMBL18975365 | 0.70 | LMNA (0.56) | LMNAHDAC1SYKCLK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10640507-B2 | PBD antibacterial agents | KING'S COLLEGE LONDON (GB) | 2020-05-05 | — | — | US | disclosed |
| US-20180354958-A1 | PBD ANTIBACTERIAL AGENTS | Secretary of State for Health and Social Care (GB) | 2018-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10640507-B2 | PBD antibacterial agents | OPRD1, XDH, SBDS | LMNA 3243/4885HDAC1 518/4885SYK 3347/4885 |
| US-20180354958-A1 | PBD ANTIBACTERIAL AGENTS | OPRD1, XDH, SBDS | LMNA 3243/4885HDAC1 518/4885SYK 3347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.