Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBOAT4 | Q96T53 | 12/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16699213 | 0.86 | MBOAT4 (0.69) | MBOAT4OPRK1 | |
| SCHEMBL16699845 | 0.85 | MBOAT4 (0.49) | MBOAT4 | |
| SCHEMBL19979147 | 0.84 | MBOAT4 (0.46) | MBOAT4 | |
| SCHEMBL19971821 | 0.82 | MBOAT4 (0.64) | MBOAT4OPRK1CHRM2CHRM1CHRM3 | |
| SCHEMBL19971822 | 0.82 | MBOAT4 (0.64) | MBOAT4OPRK1CHRM2CHRM1CHRM3 | |
| SCHEMBL16718693 | 0.82 | MBOAT4 (0.44) | MBOAT4 | |
| SCHEMBL19971824 | 0.79 | MBOAT4 (0.57) | MBOAT4OPRK1 | |
| SCHEMBL19991534 | 0.77 | MBOAT4 (0.67) | MBOAT4OPRK1CHRM2DGAT1 | |
| SCHEMBL20009392 | 0.75 | MBOAT4 (0.60) | MBOAT4OPRK1 | |
| SCHEMBL18166114 | 0.75 | MBOAT4 (0.66) | MBOAT4OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068775-B1 | SUBSTITUTED PIPERIDYL-ETHYL-PYRIMIDINE AS GHRELIN O-ACYL TRANSFERASE INHIBITOR | LILLY CO ELI (US) | 2017-09-06 | — | — | EP | disclosed |
| EP-3068775-A1 | SUBSTITUTED PIPERIDYL-ETHYL-PYRIMIDINE AS GHRELIN O-ACYL TRANSFERASE INHIBITOR | Eli Lilly and Company (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073281-A1 | SUBSTITUTED PIPERIDYL-ETHYL-PYRIMIDINE AS GHRELIN O-ACYL TRANSFERASE INHIBITOR | ELI LILLY AND COMPANY (US) | 2015-05-21 | — | — | WO | disclosed |
| US-9035051-B1 | Ghrelin O-acyl transferase inhibitor | ELI LILLY AND COMPANY (US) | 2015-05-19 | — | — | US | disclosed |
| US-20150133474-A1 | GHRELIN O-ACYL TRANSFERASE INHIBITOR | ELI LILLY AND COMPANY | 2015-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133474-A1 | GHRELIN O-ACYL TRANSFERASE INHIBITOR | MBOAT4, DGAT1, MOGAT2 | MBOAT4 1/4885OPRK1 3093/4885GRIN2D 4048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.