Sugi Predict

Sugi Predict / Compounds / SCHEMBL166999

SCHEMBL166999

SCHEMBL166999

COC(=O)Cc1ccc(S)cc1

nearest known ligand 0.63

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ CYP4F2 P78329 1/20 0.63
▸ CYP4A11 Q02928 1/20 0.63
▸ HSP90AB1 P08238 1/20 0.52
▸ ALDH1A1 P00352 4/20 0.51
▸ GAA P10253 1/20 0.51
▸ GFER P55789 1/20 0.51
▸ SMN1; SMN2 Q16637 5/20 0.47
▸ NPC1 O15118 4/20 0.47
▸ RAB9A P51151 4/20 0.47
▸ MAPT P10636 3/20 0.47
▸ TP53 P04637 2/20 0.47
▸ LMNA P02545 2/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.47
▸ KMT2A Q03164 2/20 0.46
▸ KDM4E B2RXH2 1/20 0.46
▸ HPGD P15428 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4113212 0.89 CYP4F2 (0.76) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA
SCHEMBL10829361 0.86 CYP4F2 (0.49) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA
SCHEMBL13658738 0.84 EPHX2 (0.52) CYP4F2CYP4A11ALDH1A1SMN1; SMN2NPC1
SCHEMBL8862126 0.83 CYP4F2 (0.63) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA
SCHEMBL12900169 0.83 CYP4F2 (0.63) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA
SCHEMBL21634259 0.83 CYP4F2 (0.42) CYP4F2CYP4A11ALDH1A1GAASMN1; SMN2
SCHEMBL4104271 0.81 CYP4F2 (0.66) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA
SCHEMBL5546570 0.81 CYP4F2 (0.66) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA
SCHEMBL112488 0.81 CYP4F2 (0.66) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA
SCHEMBL4613929 0.81 CYP4F2 (0.66) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 179 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12264169-B2 Heteroaryl inhibitors of PDE4 Tetra Discovery Partners (US) 2025-04-01 — — US disclosed
CN-113072542-B ROR gamma t inhibitor and preparation method and application thereof 广东东阳光药业股份有限公司 2024-04-05 — — CN disclosed
US-20230348501-A1 HETEROARYL INHIBITORS OF PDE4 Tetra Discovery Partners, LLC 2023-11-02 — — US disclosed
US-11767334-B2 Heteroaryl inhibitors of PDE4 Tetra Discovery Partners, LLC (US) 2023-09-26 — — US disclosed
US-20230210808-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS CYMABAY THERAPEUTICS, INC. 2023-07-06 — — US disclosed
US-20230121086-A1 RORgT INHIBITOR, PREPARATION METHOD THEREOF AND USE THEREOF SUNSHINE LAKE PHARMA CO., LTD. (CN) 2023-04-20 — — US disclosed
US-20230024240-A1 HETEROARYL INHIBITORS OF PDE4 Tetra Discovery Partners, LLC 2023-01-26 — — US disclosed
EP-3842420-B1 HETEROARYL INHIBITORS OF PDE4 TETRA DISCOVERY PARTNERS LLC (US) 2022-12-07 — — EP disclosed
EP-4089080-A1 RORyT INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF Sunshine Lake Pharma Co., Ltd. (CN) 2022-11-16 — — EP disclosed
EP-4083029-A1 NOVEL AND SPECIFIC INHIBITORS OF CYTOCHROME P450 26 RETINOIC ACID HYDROXYLASE University of Washington through its Center for Commercialization (US) 2022-11-02 — — EP disclosed
US-5723480-A Adhesion receptor antagonists III MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1998-03-03 — — US disclosed
US-5561148-A Adhesion receptor antagonists III MERCK PATENT GESELLSCHAFT MIT BESHRANKTER HAFTUNG (DE) 1996-10-01 — — US disclosed
EP-0645376-A1 Substituted 1-phenyl-oxazolidin-2-one derivatives, their preparation and their use as adhesion-receptor antagonists MERCK PATENT GmbH (DE) 1995-03-29 — — EP disclosed
US-5208240-A Alzeheimer's, cardiovascular, respiratory MERRELL DOW PHARMACEUTICALS INC. (US) 1993-05-04 — — US disclosed
EP-0503563-A2 Novel 8-substituted purines as selective adenosine receptor agents MERRELL PHARMACEUTICALS INC. (US) 1992-09-16 — — EP disclosed
EP-0410244-A1 Leukotriene antagonists BAYER AG (DE) 1991-01-30 — — EP disclosed
US-4720505-A Leukotriene antagonists MERCK FROSST CANADA, INC. (CA) 1988-01-19 — — US disclosed
US-4672071-A Antihypertensive dihydropyridine compositions, optical isomers and intermediates SYNTEX (U.S.A.) INC. (US) 1987-06-09 — — US disclosed
EP-0191448-A2 Antihypertensive dihydropyridine derivatives SYNTEX (U.S.A.) INC. (US) 1986-08-20 — — EP disclosed
US-4595690-A Hypotensive agents SYNTEX (U.S.A.) INC. (US) 1986-06-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230024240-A1 HETEROARYL INHIBITORS OF PDE4 PDE4A, PDE4B, PDE4C CYP4F2 495/4885CYP4A11 60/4885HSP90AB1 1414/4885
US-20230210808-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD CYP4F2 465/4885CYP4A11 150/4885HSP90AB1 947/4885
US-20230348501-A1 HETEROARYL INHIBITORS OF PDE4 PDE4A, PDE4B, PDE4C CYP4F2 495/4885CYP4A11 60/4885HSP90AB1 1414/4885
US-11767334-B2 Heteroaryl inhibitors of PDE4 PDE4A, PDE4B, PDE4C CYP4F2 495/4885CYP4A11 60/4885HSP90AB1 1414/4885
US-12264169-B2 Heteroaryl inhibitors of PDE4 PDE4A, PDE4B, PDE4C CYP4F2 495/4885CYP4A11 60/4885HSP90AB1 1414/4885
US-20230121086-A1 RORgT INHIBITOR, PREPARATION METHOD THEREOF AND USE THEREOF RORC, RORB, RORA CYP4F2 420/4885CYP4A11 55/4885HSP90AB1 1574/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.