Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | S100A4 | P26447 | 2/20 | 0.47 |
| ▸ | PTPRC | P08575 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8499259 | 0.79 | MAPT (0.66) | MAPTRECQLKMT2AMCL1RXFP1 | |
| SCHEMBL332607 | 0.76 | POLB (0.53) | MAPTRECQLKMT2AMCL1RXFP1 | |
| SCHEMBL16701466 | 0.73 | ACHE (0.55) | MAPTRECQLKMT2AMCL1RXFP1 | |
| SCHEMBL13046531 | 0.73 | S100A4 (0.47) | MAPTRECQLKMT2AMCL1RXFP1 | |
| SCHEMBL1306345 | 0.72 | MAPT (0.49) | MAPTRECQLKMT2AMCL1RXFP1 | |
| SCHEMBL10571400 | 0.72 | TDP1 (0.43) | MAPTRECQLKMT2AMCL1RXFP1 | |
| SCHEMBL166701 | 0.72 | MAPT (0.56) | MAPTRECQLKMT2AMCL1RXFP1 | |
| SCHEMBL35211484 | 0.72 | MAPT (0.56) | MAPTRECQLKMT2AMCL1RXFP1 | |
| SCHEMBL77252 | 0.72 | S100A4 (0.63) | MAPTRECQLKMT2AMCL1RXFP1 | |
| SCHEMBL29424353 | 0.72 | S100A4 (0.63) | MAPTRECQLKMT2AMCL1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160367685-A1 | DUPA-INDENOISOQUINOLINE CONJUGATES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-12-22 | — | — | US | disclosed |
| WO-2015069766-A1 | DUPA-INDENOISOQUINOLINE CONJUGATES | PURDUE RESEARCH FOUNDATION (US) | 2015-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160367685-A1 | DUPA-INDENOISOQUINOLINE CONJUGATES | PDS5B, KLK3, PDS5A | MAPT 1140/4885RECQL 31/4885KMT2A 337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.