Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 3/20 | 0.85 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.85 |
| ▸ | MAOB | P27338 | 2/20 | 0.85 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.85 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.85 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.85 |
| ▸ | BACE1 | P56817 | 15/20 | 0.65 |
| ▸ | TYR | P14679 | 2/20 | 0.62 |
| ▸ | CA12 | O43570 | 1/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | ESR1 | P03372 | 1/20 | 0.62 |
| ▸ | CA3 | P07451 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | CA4 | P22748 | 1/20 | 0.62 |
| ▸ | CA6 | P23280 | 1/20 | 0.62 |
| ▸ | DPP4 | P27487 | 1/20 | 0.62 |
| ▸ | CA5A | P35218 | 1/20 | 0.62 |
| ▸ | CA7 | P43166 | 1/20 | 0.62 |
| ▸ | CA9 | Q16790 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16702808 | 1.00 | AKR1B1 (0.85) | AKR1B1AKR1B10MAOBPTGS2GLO1 | |
| Bisdemethoxycurcumin SCHEMBL2574140 | 0.92 | AKR1B1 (1.00) | AKR1B1AKR1B10MAOBPTGS2GLO1 | |
| Bisdemethoxycurcumin SCHEMBL428638 | 0.92 | AKR1B1 (1.00) | AKR1B1AKR1B10MAOBPTGS2GLO1 | |
| Bisdemethoxycurcumin SCHEMBL28163045 | 0.90 | AKR1B1 (0.96) | AKR1B1AKR1B10MAOBPTGS2GLO1 | |
| SCHEMBL7067334 | 0.84 | HAO1 (0.75) | AKR1B1AKR1B10MAOBPTGS2GLO1 | |
| SCHEMBL10348520 | 0.84 | HAO1 (0.75) | AKR1B1AKR1B10MAOBPTGS2GLO1 | |
| SCHEMBL23728364 | 0.83 | AKR1B1 (0.81) | AKR1B1AKR1B10MAOBPTGS2GLO1 | |
| SCHEMBL1646481 | 0.83 | AKR1B1 (0.81) | AKR1B1AKR1B10MAOBPTGS2GLO1 | |
| SCHEMBL3221765 | 0.83 | AKR1B1 (0.81) | AKR1B1AKR1B10MAOBPTGS2GLO1 | |
| SCHEMBL12469736 | 0.83 | AKR1B1 (0.81) | AKR1B1AKR1B10MAOBPTGS2GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118773100-A | Recombinant escherichia coli for de novo synthesis of coumaroyl acetic acid as well as construction method and application thereof | 郑州大学 | 2024-10-15 | — | — | CN | claimed |
| US-9738605-B2 | Hybrid compounds of curcumin and melatonin as neuroprotectants for neurodegenerative disorders | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2017-08-22 | — | — | US | claimed |
| US-20160289187-A1 | HYBRID COMPOUNDS OF CURCUMIN AND MELATONIN AS NEUROPROTECTANTS FOR NEURODEGENERATIVE DISORDERS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2016-10-06 | — | — | US | claimed |
| WO-2015069970-A1 | HYBRID COMPOUNDS OF CURCUMIN AND MELATONIN AS NEUROPROTECTANTS FOR NEURODEGENERATIVE DISORDERS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2015-05-14 | — | — | WO | claimed |
| CN-118773100-A | Recombinant escherichia coli for de novo synthesis of coumaroyl acetic acid as well as construction method and application thereof | 郑州大学 | 2024-10-15 | — | — | CN | disclosed |
| CN-118773101-A | Recombinant escherichia coli for synthesizing trans-artemia from head and construction method and application | 郑州大学 | 2024-10-15 | — | — | CN | disclosed |
| CN-118773099-A | Recombinant escherichia coli for de novo synthesis of iso-preferably phenol, and construction method and application thereof | 郑州大学 | 2024-10-15 | — | — | CN | disclosed |
| CN-118773098-A | Recombinant escherichia coli for synthesizing trans-anethole from head and construction method and application thereof | 郑州大学 | 2024-10-15 | — | — | CN | disclosed |
| CN-118773100-A | Recombinant escherichia coli for de novo synthesis of coumaroyl acetic acid as well as construction method and application thereof | 郑州大学 | 2024-10-15 | — | — | CN | disclosed |
| CN-118773097-A | Recombinant escherichia coli for de novo synthesis of good-taste phenol, construction method and application | 郑州大学 | 2024-10-15 | — | — | CN | disclosed |
| CN-118773100-A | Recombinant escherichia coli for de novo synthesis of coumaroyl acetic acid as well as construction method and application thereof | 郑州大学 | 2024-10-15 | — | — | CN | disclosed |
| US-9738605-B2 | Hybrid compounds of curcumin and melatonin as neuroprotectants for neurodegenerative disorders | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2017-08-22 | — | — | US | disclosed |
| US-20160289187-A1 | HYBRID COMPOUNDS OF CURCUMIN AND MELATONIN AS NEUROPROTECTANTS FOR NEURODEGENERATIVE DISORDERS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2016-10-06 | — | — | US | disclosed |
| WO-2015069970-A1 | HYBRID COMPOUNDS OF CURCUMIN AND MELATONIN AS NEUROPROTECTANTS FOR NEURODEGENERATIVE DISORDERS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2015-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160289187-A1 | HYBRID COMPOUNDS OF CURCUMIN AND MELATONIN AS NEUROPROTECTANTS FOR NEURODEGENERATIVE DISORDERS | MTNR1A, MTNR1B, HTT | AKR1B1 1824/4885AKR1B10 1144/4885MAOB 231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.