Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1906269 | 0.81 | MGLL (0.53) | NPC1RAB9ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL6371892 | 0.81 | MGLL (0.40) | NPC1RAB9ASMN1; SMN2ALDH1A1MGLL | |
| SCHEMBL10136304 | 0.81 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1MGLL | |
| SCHEMBL16911235 | 0.78 | RAB9A (0.41) | NPC1RAB9ASMN1; SMN2NOTUMALDH1A1 | |
| SCHEMBL16912162 | 0.76 | FPR2 (0.47) | NPC1RAB9ASMN1; SMN2ALDH1A1MGLL | |
| SCHEMBL17239466 | 0.75 | MGLL (0.54) | NPC1RAB9ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL13619384 | 0.74 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2NOTUMALDH1A1 | |
| SCHEMBL12422701 | 0.72 | HTT (0.59) | NPC1RAB9ASMN1; SMN2HTTNOTUM | |
| SCHEMBL23410958 | 0.72 | HTR3A (0.42) | NPC1RAB9ASMN1; SMN2NOTUMALDH1A1 | |
| SCHEMBL11983535 | 0.72 | CCR1 (0.43) | NPC1RAB9ASMN1; SMN2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9029377-B2 | Platelet-activating factor receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2015-05-12 | — | — | US | disclosed |