Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.67 |
| ▸ | KDR | P35968 | 1/20 | 0.67 |
| ▸ | PIM1 | P11309 | 4/20 | 0.57 |
| ▸ | CDK2 | P24941 | 3/20 | 0.56 |
| ▸ | PRKACA | P17612 | 3/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | PRKCG | P05129 | 1/20 | 0.56 |
| ▸ | PRKCB | P05771 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | CDK4 | P11802 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | PRKCA | P17252 | 1/20 | 0.56 |
| ▸ | PRKACG | P22612 | 1/20 | 0.56 |
| ▸ | PRKACB | P22694 | 1/20 | 0.56 |
| ▸ | CCND1 | P24385 | 1/20 | 0.56 |
| ▸ | PRKCH | P24723 | 1/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13596802 | 0.91 | PRKCB (0.72) | FLT3KDRPIM1CDK2PRKACA | |
| SCHEMBL5879226 | 0.90 | FLT3 (0.57) | FLT3KDRPIM1CDK2PRKACA | |
| SCHEMBL29541048 | 0.88 | FLT3 (0.58) | FLT3KDRPIM1CDK2PRKACA | |
| SCHEMBL19216935 | 0.83 | KDR (0.60) | FLT3KDRPIM1CDK2PRKACA | |
| SCHEMBL5618155 | 0.82 | TGFBR1 (0.71) | FLT3PIM1CDK2PRKACAPRKD3 | |
| SCHEMBL1155501 | 0.82 | KDR (1.00) | FLT3KDRCDK2ABL1CDK4 | |
| SCHEMBL5879310 | 0.81 | FLT3 (0.49) | FLT3KDRPIM1CDK2PRKACA | |
| Hydrochloric Acid SCHEMBL5571287 | 0.81 | KDR (0.98) | FLT3KDRCDK2ABL1CDK4 | |
| Hydrochloric Acid SCHEMBL5571286 | 0.80 | KDR (0.96) | FLT3KDRCDK2ABL1CDK4 | |
| SCHEMBL1050911 | 0.77 | TGFBR1 (0.60) | FLT3PIM1CDK2PRKACAPRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160024497-A1 | Compositions And Methods For Inhibiting Expression Of GSK-3 Genes | ALNYLAM PHARMACEUTICALS, INC. | 2016-01-28 | — | — | US | disclosed |
| US-9029525-B2 | Compositions and methods for inhibiting expression of GSK-3 genes | ALNYLAM PHARMACEUTICALS, INC. (US) | 2015-05-12 | — | — | US | disclosed |