Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | ATF4 | P18848 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4207158 | 0.74 | POLB (0.60) | POLBBLMTDP1MAPTALDH1A1 | |
| SCHEMBL4203506 | 0.73 | CYP3A4 (0.69) | POLBBLMTDP1MAPTALDH1A1 | |
| SCHEMBL8795385 | 0.71 | POLB (0.61) | POLBBLMTDP1MAPTALDH1A1 | |
| SCHEMBL4088281 | 0.71 | SLC6A3 (0.47) | ALDH1A1PKMKMT2A | |
| SCHEMBL8800604 | 0.71 | ALDH1A1 (0.56) | POLBMAPTALDH1A1HPGDKMT2A | |
| SCHEMBL4205316 | 0.71 | POLB (0.60) | POLBBLMTDP1MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL8487010 | 0.70 | POLB (0.59) | POLBBLMTDP1MAPTALDH1A1 | |
| SCHEMBL1118437 | 0.70 | GPR119 (0.66) | POLBBLMTDP1MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL1661798 | 0.70 | GPR119 (0.65) | POLBBLMTDP1MAPTALDH1A1 | |
| SCHEMBL12615985 | 0.70 | NOTUM (0.78) | POLBBLMTDP1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280704-B1 | OXYMETHYLENE ARYL COMPOUNDS AND USES THEREOF | CYMABAY THERAPEUTICS INC (US) | 2015-05-13 | — | — | EP | disclosed |