Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL827877 | 0.81 | LMNA (0.49) | POLBKDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL29375415 | 0.79 | BACE1 (0.55) | POLBKDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL2191375 | 0.79 | BACE1 (0.55) | POLBKDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL3532637 | 0.79 | HTR3A (0.46) | POLBKDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL9184397 | 0.79 | KDM4E (0.42) | POLBKDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL31179390 | 0.79 | HTR3A (0.46) | POLBKDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL18379257 | 0.78 | BCL2L11 (0.43) | POLBKDM4EHPGDALDH1A1BCL2L11 | |
| SCHEMBL18368398 | 0.77 | BCL2L1 (0.56) | POLBKDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL160602 | 0.73 | BTK (0.47) | POLBKDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL4822352 | 0.73 | ALDH1A1 (0.65) | POLBALDH1A1L3MBTL1TDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346830-B1 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK SHARP & DOHME (US) | 2015-05-13 | — | — | EP | disclosed |