Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 3/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17919704 | 0.81 | CYP2A6 (0.52) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL19414340 | 0.78 | NPC1 (0.41) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL29024744 | 0.78 | ALDH1A1 (0.45) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL2671991 | 0.78 | THRB (0.44) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL23980728 | 0.76 | NPC1 (0.40) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL1536432 | 0.76 | KDM4E (0.57) | NPC1RAB9AMAPTKDM4EGABRP | |
| SCHEMBL30746959 | 0.76 | KDM4E (0.57) | NPC1RAB9AMAPTKDM4EGABRP | |
| SCHEMBL19798862 | 0.75 | RAB9A (0.41) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL12416723 | 0.75 | NPC1 (0.39) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL17919945 | 0.75 | CYP1A2 (0.48) | NPC1RAB9ACASP3SENP7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346830-B1 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK SHARP & DOHME (US) | 2015-05-13 | — | — | EP | disclosed |