Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17919704 | 0.79 | CYP2A6 (0.52) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL16705379 | 0.76 | NPC1 (0.41) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL2671991 | 0.76 | THRB (0.44) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL29024744 | 0.76 | ALDH1A1 (0.45) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL19414340 | 0.76 | NPC1 (0.41) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL16294333 | 0.76 | SCN9A (0.53) | NPC1RAB9AMAPTKDM4E | |
| SCHEMBL1536432 | 0.75 | KDM4E (0.57) | NPC1RAB9AMAPTCYP1A2KDM4E | |
| SCHEMBL8445262 | 0.75 | NNMT (0.44) | MAPTCYP1A1CYP1A2CYP1B1KDM4E | |
| SCHEMBL30746959 | 0.75 | KDM4E (0.57) | NPC1RAB9AMAPTCYP1A2KDM4E | |
| SCHEMBL19798862 | 0.74 | RAB9A (0.41) | NPC1RAB9ACASP3SENP7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222542-A1 | 5-AMINO-2-PIPERIDINON-3-YL-1-OXOISOINDOLINE DERIVATIVES FOR DEGRADATION OF IKZF2 DEGRADERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-11-04 | — | — | WO | disclosed |