Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | VHL | P40337 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751904 | 0.87 | VHL (0.54) | SMN1; SMN2VHLCA12CA1CA2 | |
| SCHEMBL26148033 | 0.81 | ADRB2 (0.42) | SMN1; SMN2VHLCA12CA1CA2 | |
| SCHEMBL25601889 | 0.79 | KLK7 (0.41) | SMN1; SMN2CA12CA1CA2CA9 | |
| SCHEMBL19598756 | 0.78 | PPARA (0.45) | SMN1; SMN2CA12CA1CA2CA9 | |
| SCHEMBL24348876 | 0.78 | VHL (0.42) | SMN1; SMN2VHLALDH1A1MAPTRAB9A | |
| SCHEMBL25603628 | 0.76 | PPARA (0.52) | SMN1; SMN2CA12CA1CA2CA9 | |
| SCHEMBL25602002 | 0.75 | SMPD1 (0.47) | SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24838097 | 0.75 | SMPD1 (0.47) | SMN1; SMN2KDM4EALDH1A1MEN1PKM | |
| SCHEMBL25227460 | 0.74 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1MEN1MAPTHTT | |
| SCHEMBL21159080 | 0.73 | LMNA (0.43) | CA12CA1CA2CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646446-B1 | BROMODOMAIN INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS INC (US) | 2015-05-13 | — | — | EP | disclosed |