Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4294715 | 0.95 | ALDH1A1 (0.53) | ALDH1A1ACHECYP3A4MAPK1TDP1 | |
| SCHEMBL145855 | 0.87 | ALDH1A1 (0.62) | ALDH1A1ACHECYP3A4TSHRMAPK1 | |
| SCHEMBL29587173 | 0.84 | ALDH1A1 (0.59) | ALDH1A1ACHECYP3A4TSHRMAPK1 | |
| SCHEMBL12501 | 0.81 | ALDH1A1 (0.73) | ALDH1A1ACHECYP3A4TSHRMAPK1 | |
| SCHEMBL16116743 | 0.79 | ALDH1A1 (0.42) | ALDH1A1ACHECYP3A4TSHRMAPK1 | |
| SCHEMBL4342018 | 0.77 | ALDH1A1 (0.50) | ALDH1A1ACHECYP3A4TSHRMAPK1 | |
| SCHEMBL879948 | 0.75 | ALDH1A1 (0.60) | ALDH1A1ACHECYP3A4TSHRMAPK1 | |
| SCHEMBL388060 | 0.75 | ALDH1A1 (0.48) | ALDH1A1ACHECYP3A4TSHRMAPK1 | |
| SCHEMBL29427076 | 0.75 | ALDH1A1 (0.48) | ALDH1A1ACHECYP3A4TSHRMAPK1 | |
| SCHEMBL2952197 | 0.74 | ALDH1A1 (0.53) | ALDH1A1ACHECYP3A4PTPN1CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9770432-B2 | Deuterated benzopyran compounds and the use in the treatment of pain and inflammation | GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2017-09-26 | — | — | US | disclosed |
| US-9763914-B2 | Deuterated benzopyran compounds and application thereof | GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2017-09-19 | — | — | US | disclosed |
| US-9676719-B2 | Phenyl derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2017-06-13 | — | — | US | disclosed |
| US-20170020843-A1 | DEUTERATED BENZOPYRAN COMPOUNDS AND APPLICATION THEREOF | INFLAMAX PHARMACEUTICALS LIMITED (CN) | 2017-01-26 | — | — | US | disclosed |
| US-20160287556-A1 | DEUTERATED BENZOPYRAN COMPOUNDS AND APPLICATION THEREOF | INFLAMAX PHARMACEUTICALS LIMITED (CN) | 2016-10-06 | — | — | US | disclosed |
| US-9371305-B2 | Deuterated benzopyran compounds and application thereof | GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2016-06-21 | — | — | US | disclosed |
| US-20150133538-A1 | Deuterated Benzopyran Compounds and Application Thereof | GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2015-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133538-A1 | Deuterated Benzopyran Compounds and Application Thereof | PTGS2, HPGDS, PTGS1 | ALDH1A1 324/4885ACHE 2101/4885CYP3A4 129/4885 |
| US-20160287556-A1 | DEUTERATED BENZOPYRAN COMPOUNDS AND APPLICATION THEREOF | PTGS2, HPGDS, PTGS1 | ALDH1A1 324/4885ACHE 2101/4885CYP3A4 129/4885 |
| US-20170020843-A1 | DEUTERATED BENZOPYRAN COMPOUNDS AND APPLICATION THEREOF | PTGS2, HPGDS, PTGS1 | ALDH1A1 324/4885ACHE 2101/4885CYP3A4 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.