Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | BACE1 | P56817 | 3/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12198419 | 0.86 | ADRB2 (0.46) | TEAD1BCHEACHEBACE1ADRB2 | |
| SCHEMBL1668262 | 0.84 | KDM4E (0.48) | TEAD1BCHEACHEBACE1ADRB2 | |
| SCHEMBL1668670 | 0.81 | HTR2C (0.35) | BCHEACHEBACE1ADRB2PIK3CA | |
| SCHEMBL1669073 | 0.80 | PPARD (0.39) | KCNH2GPR119KDM4EALDH1A1 | |
| SCHEMBL1668306 | 0.80 | KMT2A (0.43) | ACHEMCHR1DRD4 | |
| SCHEMBL1668410 | 0.78 | KDM4E (0.49) | PIK3CAPRKAA2KCNH2GPR119KDM4E | |
| SCHEMBL12198321 | 0.78 | KDM4E (0.52) | TEAD1ADRB2PIK3CAPRKAA2KCNH2 | |
| SCHEMBL12198420 | 0.77 | KDM4E (0.50) | TEAD1BCHEACHEBACE1ADRB2 | |
| SCHEMBL1671394 | 0.76 | EPHX2 (0.46) | PIK3CAPRKAA2KCNH2GPR119KDM4E | |
| SCHEMBL1668787 | 0.75 | KDM4E (0.51) | TEAD1BCHEACHEBACE1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486033-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2012-08-15 | — | — | EP | claimed |
| WO-2011044001-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2011-04-14 | — | — | WO | claimed |